Assessment of knowledge about malaria and LLIN ownership and its use in Bankura, West Bengal, India.

Background & Objectives: Community participation is one of the key factors for implementation and success of a public health programme which depends upon knowledge about that disease. Therefore, understanding the community knowledge about malaria is important for designing sustainable control programmes. This study was conducted to assess the knowledge about malaria, to evaluate long lasting insecticidal nets (LLINs) distribution and their use by LQAS method in endemic areas of Bankura district, West Bengal state, India Methods: It was a community based cross-sectional survey conducted in Bankura during December 2019-March 2020.

and A Genes Comprising G-Quadruplex as Promising Therapeutic Targets against : Molecular Recognition by Mitoxantrone Suppresses Replication and Gene Regulation.

Occurrence of non-canonical G-quadruplex (G4) DNA structures in the genome have been recognized as key factors in gene regulation and several other cellular processes. The and involved in pathways of oxidation sensing regulation and ATP generation, respectively, make () bacteria responsible for oxidative stress inside host macrophage cells. Circular Dichroism spectra demonstrate stable hybrid G4 DNA conformations of / DNA sequences.

Erratum: Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity.

[This corrects the article DOI: 10.1016/j.omtn.

Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity.

G-quadruplex is a non-canonical secondary structure identified in the telomeric region and the promoter of many oncogenes. Anthraquinone derivatives, a well-known inducer of telomere disruption in malignant cells and activate the apoptotic pathway. We used biophysical and biochemical studies to confirm the interaction of synthesized anthraquinone derivatives with the human telomeric G-quadruplex sequence.

Molecular rec§ognition of telomere DNA sequence by 2, 6 anthraquinone derivatives leads to thermal stabilization and induces apoptosis in cancer cells.

According to current research, anti-cancer anthraquinones impact telomere disruption and may interact with G-quadruplex DNA that triggers signaling to apoptosis. The present study represents the biophysical investigation of oxidative stress, late apoptosis, and induced senescence among cancer cells after binding laboratory synthesized piperidine-based anthraquinone derivatives, 2, 6- Bis [(3-piperidino)acetamido)]anthracene-9,10-dione (N1P) and 2, 6-Bis [piperidino)propionamido]anthracene-9,10-dione (N2P), with G-quadruplex DNA. We employed biophysical approaches to explore the interaction of synthetic anthraquinone derivatives with quadruplex DNA sequences to influence biological activities in the presence of K and Na cations.

Green synthesis and characterization of zinc oxide nanoparticles using leaf extract of Thryallis glauca (Cav.) Kuntze and their role as antioxidant and antibacterial.

The present work has reported a green chemistry-based approach for the synthesis of crystalline metal oxide nanoparticle using plant extract to reduce metal ions. It demonstrated the efficient synthesis of Zinc oxide nanoparticles (ZnO NPs) using aqueous leaf extract of Thryallis glauca (Cav.) Kuntze with a focus on minimizing toxic reactants and byproducts.

Synthesis and Characterization of Andrographolide Derivatives as Regulators of βAPP Processing in Human Cells.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, one of the main characteristics of which is the abnormal accumulation of amyloid peptide (Aβ) in the brain. Whereas β-secretase supports Aβ formation along the amyloidogenic processing of the β-amyloid precursor protein (βAPP), α-secretase counterbalances this pathway by both preventing Aβ production and triggering the release of the neuroprotective sAPPα metabolite. Therefore, stimulating α-secretase and/or inhibiting β-secretase can be considered a promising anti-AD therapeutic track.

On the Observation of Wild Zebrafish () in India.

Zebrafish is one of the world's most widely used laboratory species, and it is utilized to answer important research questions in disparate fields such as biomedicine, genetics, developmental biology, pharmacology, toxicology, physiology, and evolution. Despite their popularity, very little is known about the biology of zebrafish in their natural habitat. This may, in part, be due to the difficulties associated with undertaking field trips to the remote areas of northern India, Nepal, and Bangladesh, which is the natural distribution range of zebrafish.

Are model organisms representative for climate change research? Testing thermal tolerance in wild and laboratory zebrafish populations.

Model organisms can be useful for studying climate change impacts, but it is unclear whether domestication to laboratory conditions has altered their thermal tolerance and therefore how representative of wild populations they are. Zebrafish in the wild live in fluctuating thermal environments that potentially reach harmful temperatures. In the laboratory, zebrafish have gone through four decades of domestication and adaptation to stable optimal temperatures with few thermal extremes.

Assessment of heavy metal contamination in two edible fish species Carassius carassius and Triplophysa kashmirensis of Dal Lake, Srinagar, Kashmir, India.

The present study was aimed to examine the concentration of heavy metals in the two edible fish species Carassius carassius and Triplophysa kashmirensis of the Dal Lake (Srinagar, Jammu, and Kashmir, India). Metals cadmium (Cd), manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), and chromium (Cr) were analyzed using atomic absorption spectroscopy (AAS). Differences in the heavy metal accumulation were observed between the two species as well as between different sizes of the same species.

Application of Computational Techniques to Unravel Structure-Function Relationship and their Role in Therapeutic Development.

Application of computational tools and techniques has emerged as an invincible instrument to unravel the structure-function relationship and offered better mechanistic insights in the designing and development of new drugs along with the treatment regime. The use of in silico tools equipped modern chemist with armamentarium of extensive methods to meticulously comprehend the structural tenacity of receptor-ligand interactions and their dynamics. In silico methods offers a striking property of being less resource intensive and economically viable as compared to experimental evaluation.

Biased paternal transmission of TRH variant to female Down syndrome probands: possible correlation with low breast cancer frequency.

Thyroid malfunction is more common in individuals with Down syndrome (DS) than in the general population. It has been hypothesized that thyroid may influence cancer risk. Individuals with DS are at greater risk of developing leukemia than the general population, while solid tumors especially breast cancer (BC) are rare.

Down Syndrome Related Muscle Hypotonia: Association with COL6A3 Functional SNP rs2270669.

Down syndrome (DS), the principal cause for intellectual disability, is also associated with hormonal, immunological, and gastrointestinal abnormalities. Muscle hypotonia (MH) and congenital heart diseases (CHD) are also frequently observed. Collagen molecules are essential components for maintaining muscle integrity and are formed by the assembly of three chains, alpha 1-3.