Publications by authors named "Arpinder Bal"
Background & Aims: Primary sclerosing cholangitis (PSC) is an immune-mediated cholestatic liver disease for which there is an unmet need to understand the cellular composition of the affected liver and how it underlies disease pathogenesis. We aimed to generate a comprehensive atlas of the PSC liver using multi-omic modalities and protein-based functional validation.
Methods: We employed single-cell and single-nucleus RNA sequencing (47,156 cells and 23,000 nuclei) and spatial transcriptomics (one sample by 10x Visium and five samples with Nanostring GeoMx DSP) to profile the cellular ecosystem in 10 PSC livers.
Article Synopsis
- * The study will involve 240 patients and compare the effectiveness of a structured peer-delivered psychosocial support intervention alongside usual care against usual care alone, measuring outcomes like mental health-related quality of life, depression, and social support.
- * A mixed-methods evaluation will assess both effectiveness and implementation outcomes, incorporating surveys and focus groups to understand acceptability, feasibility, and the context of the intervention from the perspectives of patients, counselors, and healthcare providers.