Hospital Admissions Associated With Medication-Related Problems in Thai Older Patients: A Multicenter Prospective Observational Study.

Objective: The aim of the study was to estimate the prevalence rate and risk factors of medication-related problems (MRPs) leading to hospital admissions in Thai older patients.

Methods: A prospective observational study was carried out in nine hospitals in Lower Northern Thailand. Participants admitted to internal medicine units were screened for suspected MRPs by clinical pharmacists using medical record review and patient interview.

Trends and predictors of high-intensity statin therapy and LDL-C goal achievement among Thai patients with acute coronary syndrome.

Background: Previous studies on the use of high-intensity statins and low-density lipoprotein cholesterol (LDL-C) goal achievement were mostly conducted in patients with acute coronary syndrome (ACS) receiving care before 2013. We aimed to determine trends and predictors of high-intensity statin therapy and LDL-C goal achievement in a more recent cohort of Thai ACS patients.

Methods: We analyzed data from electronic databases of ACS patients at a tertiary-care, teaching hospital in Thailand between 2013 and 2017.

Prevalence and Predictors of Statin Treatment Among Patients With Chronic Heart Failure at a Tertiary-Care Center in Thailand.

Background: Statins play important roles in the prevention of atherosclerotic vascular diseases; however, their beneficial effects in patients with chronic heart failure (CHF) are uncertain. This study aimed to investigate the prevalence and predictors of treatment with statins to better understand their prescribing patterns in CHF patients.

Methods: We conducted a cross-sectional study in patients with first-time diagnoses of CHF receiving care in the outpatient clinics affiliated with a tertiary-care teaching hospital in Thailand.

Attributable Costs of Postoperative Atrial Fibrillation among Patients Undergoing Cardiac Surgery.

Background: Postoperative atrial fibrillation (POAF) is the most common complication among patients undergoing cardiac surgery. However, data on the economic burden and resource utilization associated with POAF in Asian population are limited. The present study aimed at estimating medical costs attributable to POAF after cardiac surgery in Thai population.

Hospital Outpatient Visits Associated With Medication-Related Problems in Thailand: A Multicenter Prospective Observational Study.

Objectives: The aims of the study were to investigate the prevalence of hospital visits associated with medication-related problems (MRPs, i.e., adverse drug events [ADEs], adverse drug reactions [ADRs], nonadherence [NA] to medication, and medication error) and to identify the medications involved in hospital visits associated with MRPs in outpatient departments (OPDs).

Patterns and adherence to guidelines of antithrombotic therapy in Thai patients with nonvalvular atrial fibrillation.

Background: Antithrombotic therapy is essential in patients with atrial fibrillation (AF) to prevent systemic thromboembolism, particularly ischemic stroke. Several studies conducted in North America and European countries revealed that AF patients at high risk for thromboembolism did not adequately receive antithrombotic therapy as recommended by relevant guidelines. However such a few studies were reported from Asian countries.

Rate and predictors of early readmission among Thai patients with heart failure.

Background: Readmission to hospital after discharge has been recognized as a significant problem in patients with chronic heart failure (CHF). No studies report rate of early readmission (defined as readmission within 30 days after discharge) and its predictors among Thai patients with CHE.

Objective: To determine rate and predictors of early readmission among Thai patients with heart failure.

Validation of electronic medical database in patients with atrial fibrillation in community hospitals.

Background: The electronic medical database (EMD) has been increasingly used for clinical research as it reflects a real-world practice with large and heterogeneous samples. However, few studies have reported on the validity of EMD from community hospitals for research purposes.

Objective: To assess the validity of EMD based on data from patients with atrial fibrillation (AF) receiving care from community hospitals in Phitsanulok Province, Thailand.

TA205, an anti-talin monoclonal antibody, inhibits integrin-talin interaction.

Talin mediates integrin signaling by binding to integrin cytoplasmic tails through its FERM domain which consists of F1, F2 and F3 subdomains. TA205, an anti-talin monoclonal antibody, disrupts actin stress fibers and focal adhesion when microinjected into fibroblasts. Here, we showed that TA205 caused an allosteric inhibition of integrin alphaIIb beta3 binding to the talin FERM domain and mapped the TA205 epitope to residues 131-150 in talin F1.