Harnessing machine learning algorithms for the prediction and optimization of various properties of polylactic acid in biomedical use: a comprehensive review.

Machine learning (ML) has emerged as a transformative tool in various industries, driving advancements in key tasks like classification, regression, and clustering. In the field of chemical engineering, particularly in the creation of biomedical devices, personalization is essential for ensuring successful patient recovery and rehabilitation. Polylactic acid (PLA) is a material with promising potential for applications like tissue engineering, orthopedic implants, drug delivery systems, and cardiovascular stents due to its biocompatibility and biodegradability.

Two-Dimensional Metal-Organic Framework Incorporated Highly Polar PVDF for Dielectric Energy Storage and Mechanical Energy Harvesting.

Here, we introduce a 2D metal-organic framework (MOF) into the poly(vinylidene fluoride) (PVDF) matrix, which has been comparatively less explored in this field. Highly 2D Ni-MOF has been synthesized in this regard via hydrothermal route and has been incorporated into PVDF matrix via solvent casting technique with ultralow filler (0.5 wt%) loading.

Analysis of diffusion of plant metabolites from polyethylene glycol hydrogels using free volume theory.

The present work aims to comprehensively analyze the diffusion of plant metabolites from the polyethylene glycol (PEG) hydrogels for controlled release applications. For this study, a mathematical model based on free volume theory has been utilized to simulate the diffusion of low molecular weight plant metabolites. The results demonstrate that the mesh size of the crosslinked network, thereby the diffusion coefficient of the natural compound can be computed using the current framework.

Collagen-I/silk-fibroin biocomposite exhibits microscalar confinement of cells and induces anisotropic morphology and migration of embedded fibroblasts.

Microstructural anisotropy of tumor-associated matrix correlates with invasion of cancer cells into the surrounding matrix during metastasis. Here, we report the fabrication and characterization of a three-dimensional (3D) silk-fibroin/collagen-I bio-composite based cell-culture model that exhibits microstructural and biochemical anisotropy. Using RGD-deficient silk-fibroin fibers to confine collagen-I gelation, we develop a silk-fibroin/collagen-I (SFC) bio-composite in a one-step process allowing control over the microstructural and biochemical anisotropy and the pore-size.