Salicylate excretion in the rat; free flow micropuncture experiments.

As in other animals, the renal clearance of salicylate in the rat is greater when the urine is alkaline than when it is acid. In none of the present experiments was the rate of salicylate excretion greater than the rate of its glomerular filtration. Nevertheless, net secretion of salicylate was observed in the proximal tubules of alkalotic, nonalkalotic diuretic, and normal hydropenic animals when the plasma concentration of salicylate was below 150 microgram/ml.

The effects of 2,4,6-triaminopyrimidine (TAP) on sodium and potassium excretion by the rat kidney: comparison with amiloride.

2,4,6-Triaminopyrimidine (TAP) has been reported to be a blocker of the cation-specific paracellular conductance pathways of several epithelia. The compound is also known to inhibit sodium transport in the frog skin. Its effects on renal function were studied in clearance experiments in anesthetized rats and in isolated perfused rat kidneys and compared with the effects of amiloride.