Publications by authors named "Arnoud Spies"
Article Synopsis
- The ongoing development of conjugate vaccines highlights the need for new carriers, with outer-membrane vesicles (OMVs) proving to be a promising alternative due to their self-adjuvanting properties and ideal size for vaccine components.
- A new FFF-MALS method was developed for characterizing OMVs in terms of size and purity, utilizing particle-size standards and model proteins for precise analysis, validated under ICH Guidelines Q2 (R1).
- The method successfully assessed the purification of proprietary OMVs and confirmed that functionalizing them with GMBS did not compromise their structural integrity, allowing for further evaluation.
