Development and treatment of tertiary hyperparathyroidism in patients with pseudohypoparathyroidism type 1B.

Context: Pseudohypoparathyroidism type 1B (PHP1B) patients have PTH resistance at the renal proximal tubule and develop hypocalcemia and secondary hyperparathyroidism. Hyperparathyroid bone disease also develops in some patients. PHP1B patients are at theoretical risk of developing tertiary hyperparathyroidism.

Orbital inflammatory disease in a patient treated with zoledronate.

Objective: To increase awareness of orbital inflammatory disease as a rare adverse effect of bisphosphonates.

Methods: We present a case report and a review of the relevant literature.

Results: A 57-year-old woman with history of esophageal, breast, and lung cancers was diagnosed with postmenopausal osteoporosis.

Symptomatic and scintigraphic improvement after intravenous pamidronate treatment of Paget's disease of bone in patients with normal serum alkaline phosphatase levels.

Objective: To describe three patients with symptomatic Paget's disease of bone who presented with normal levels of serum alkaline phosphatase.

Methods: We present three cases of Paget's disease of bone and chronicle the laboratory, scintigraphic, and clinical findings relative to treatment with intravenously administered pamidronate.

Results: Although measurement of serum total alkaline phosphatase usually provides a general indication of bone turnover in Paget's disease, about 15% of patients present with normal serum alkaline phosphatase levels.

Central diabetes insipidus due to cytomegalovirus infection of the hypothalamus in a patient with acquired immunodeficiency syndrome: a clinical, pathological, and immunohistochemical case study.

We report a case of central diabetes insipidus (CDI) in a patient with AIDS due to cytomegalovirus (CMV) infection of the vasopressin-producing areas of the hypothalamus. The clinical diagnosis is established by definitive clinical and laboratory evidence of CDI. Detailed histopathological and immunohistochemical studies establish CMV as the causative agent and demonstrate the deficit of vasopressin in the synthesizing neurons.

Dramatic improvement of BMD following vitamin D therapy in a bone marrow transplant recipient.

Bone marrow transplantation is now an established successful treatment for several hematologic malignancies. Bone loss is among the long-term adverse effects of this procedure. The underlying pathophysiology is believed to be multifactorial.