Publications by authors named "Arne Grossklaus"
Article Synopsis
- The study investigated how rotigotine, a drug for treating Parkinson's disease, can be delivered through human skin using iontophoresis, a method that uses electric currents to enhance drug transport.
- The experiment involved assessing various factors including drug concentration, co-ion molecular weight, skin type, and temperature, all of which influenced the rate of drug transport.
- Results showed that higher drug concentration and temperature improved drug flux, with a maximum delivery rate indicating a potential for effective drug delivery using a reasonable-sized patch.
To validate the efficacy and controllability of a newly developed transdermal delivery system for R-apomorphine in combination with the surfactant pretreatment, iontophoresis was performed in three-chamber continuous-flow-through diffusion cells in vitro. The transdermal iontophoretic transport of R-apomorphine was examined with both human SC and freshly dermatomed human skin, at room temperature and at 32 degrees C. Furthermore, the relationship between current density and iontophoretic flux was investigated.
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