Do patients with large vessel occlusion ischemic stroke harboring prestroke disability benefit from thrombectomy?

Objectives: Evidence of endovascular treatment (EVT) for acute large vessel occlusion (LVO) ischemic stroke in patients harboring substantial prestroke disability is lacking due to their exclusion from randomized trials. Here, we used routine care observational data to compare outcomes in patients with and without prestroke disability receiving EVT for LVO ischemic stroke.

Methods: Consecutive patients undergoing EVT for acute LVO ischemic stroke at the Sahlgrenska University Hospital from January 1st, 2015 to March 31st, 2018 were registered in the Sahlgrenska Stroke Recanalization Registry.

Role of sympathetic nervous system in activity-induced cerebral perfusion.

Several studies have suggested that autonomic neural control plays a role in regulation of cerebral blood flow (CBF), although the exact role of the sympathetic nervous system on CBF remains debated. The effects of sympathetic innervation on activity-induced cerebral perfusion changes in humans have not been studied. The aims of this study were therefore (a) to investigate patients with an "intrinsic" sympathetic deficit after stroke and healthy controls with regard to activity-induced cerebral perfusion changes, and (b) to investigate possible differences in functional CBF regulation between the anterior and posterior circulation.

Effect of sympathetic muscle vasoconstrictor activity on capsaicin-induced muscle pain.

Neuropathic pain syndromes with sympathetically maintained pain are often associated with a deep somatic pain component. An adrenergic interaction between sympathetic vasoconstrictor neurons and cutaneous afferents has been demonstrated. To determine whether a sympathetic-afferent interaction exists in deep somatic tissues, we investigated the effect of sympathetic muscle vasoconstrictor activity on experimentally induced pain.