Publications by authors named "Arndt A"

Objective: This study was to investigate alterations in contractile properties of the ankle plantar- and dorsiflexors in post-stroke individuals. The correlation between muscle architecture parameters and contractile properties was also evaluated.

Methods: Eight post-stroke individuals and eight age-matched healthy subjects participated in the study.

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  • * Twelve resistance-trained males participated in the jumps, with data collected on various stiffness measures during the eccentric phase, revealing strong correlations between the different methods used.
  • * Results indicate that the force plate-only method is valid for calculating stiffness and is comparable to 3D leg stiffness, which has implications for performance evaluation and injury risk assessment.
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Leopard sharks () are temperate, Eastern Pacific elasmobranchs popular in public aquariums. Blood analysis is commonly used for assessing animal health, yet reference values have not been established for this species. This study analyzed population data to characterize blood reference values for a collection of housed at a public aquarium.

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  • A case is reported involving a patient with advanced non-small cell lung adenocarcinoma who has been on crizotinib therapy and developed a new missense mutation in the ALK gene associated with resistance to this treatment.
  • The EML4/ALK translocation remained detectable despite the patient's cancer recurrence, and a 3D analysis suggested that the mutation contributes to crizotinib resistance while showing potential sensitivity to other drugs like brigatinib and lorlatinib.
  • The study emphasizes the effectiveness of combining preclinical and clinical approaches, including targeted sequencing and in vitro validation, which could enhance the use of molecular tumor boards in improving individualized cancer treatment strategies.
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Web-based interventions can be effective in treating depressive symptoms. Patients with risk not responding to treatment have been identified by early change patterns. This study aims to examine whether early changes are superior to baseline parameters in predicting long-term outcome.

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Histopathological assessment of tissue samples after prolonged formalin fixation has been described previously, but currently there is only limited knowledge regarding the feasibility of molecular pathology on such tissue. In this pilot study, we tested routine molecular pathology methods (DNA isolation, DNA pyrosequencing/next-generation sequencing, DNA methylation analysis, RT-PCR, clonality analysis and fluorescence in situ hybridization) on tissue samples from 11 tumor entities as well as non-neoplastic brain tissue from 43 body donors during the gross anatomy course at Ulm University (winter semester 2019/20 and 2020/21). The mean post mortem interval until fixation was 2.

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Introduction: Gymnastics consists of several different disciplines, whereof TeamGym is one. TeamGym is a young discipline with sparse research. The aim of the study is to investigate the injury characteristics in Swedish elite gymnasts competing in TeamGym including training load and other physical and psychological factors associated with injury.

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Crayfish rely on their chemosensory system for many essential behaviours including finding food, finding mates, and to recognize individuals. Copper can impair chemosensation in crayfish at low concentrations; however, it is not clear if the effect is ameliorated once copper is removed. To better understand the effect of and recovery from copper exposure in crayfish, we exposed Northern clearwater crayfish (Faxonius propinquus) to 31.

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[Correction Notice: An Erratum for this article was reported online in on Sep 19 2024 (see record 2025-24490-001). The name of the author, Amy N. Arndt was incorrectly omitted from the author list in the original article.

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Background: Undifferentiated pleomorphic sarcoma (UPS) accounts for approximately 15% of all soft-tissue sarcoma (STS) cases and have a 5-year survival prognosis of around 60%. Due to its complexity, tumors are often identified by clinical and pathological exclusion. UPS is commonly found in the extremities, so finding them in the trunk and chest wall is rare.

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To facilitate pre-clinical animal and in-silico clinical trials for implantable pulmonary artery pressure sensors, understanding the respective species pulmonary arteries (PA) anatomy is important. Thus, morphological parameters describing PA of pigs and sheep, which are common animal models, were compared with humans. Retrospective computed tomography data of 41 domestic pigs (82.

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To assess whether in-silico models can be used to predict the risk of thrombus formation in pulmonary artery pressure sensors (PAPS), a chronic animal study using pigs was conducted. Computed tomography (CT) data was acquired before and immediately after implantation, as well as one and three months after the implantation. Devices were implanted into 10 pigs, each one in the left and right pulmonary artery (PA), to reduce the required number of animal experiments.

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  • Testing for EGFR mutations is crucial for metastatic non-squamous non-small-cell lung cancer, but practical challenges like access to testing and limited tissue samples hinder routine biomarker testing in European labs.
  • A validated online survey conducted among 64 expert labs revealed varying turnaround times and testing practices, with a significant portion only conducting EGFR testing upon clinician request.
  • Despite these issues, testing rates remained stable during the COVID-19 pandemic, but overall there is significant variability in testing methods and quality assurance across different European laboratories.
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Developing the ability to habitually walk and run upright on two feet is one of the most significant transformations to have occurred in human evolution. Many musculoskeletal adaptations enabled bipedal locomotion, including dramatic structural changes to the foot and, in particular, the evolution of an elevated medial arch. The foot's arched structure has previously been assumed to play a central role in directly propelling the center of mass forward and upward through leverage about the toes and a spring-like energy recoil.

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Introduction: Multi-professional interdisciplinary tumor boards (ITB) are essential institutions to discuss all newly diagnosed, relapsed or complex cancer patients in a team of specialists to find an optimal cancer care plan for each individual patient with regard to national and international clinical practice guidelines, patient´s preference and comorbidities. In a high-volume cancer center, entity-specific ITBs take place at least once a week discussing a large number of patients. To a high level of expertise and dedication, this also requires an enormous amount of time for physicians, cancer specialists and administrative support colleagues, especially for radiologists, pathologists, medical oncologists and radiation oncologists, who must attend all cancer-specific boards according to certification requirements.

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Background: Adenoviruses belong to the stable nonenveloped viruses playing an important role in healthcare-associated infections mainly causing respiratory infections and epidemic keratoconjunctivitis. Hand disinfection with alcoholic preparations is therefore one of the most important measures to prevent such viral infections in hospitals and other medical settings.

Methods: The inactivation of adenovirus type 5 by ethanol, 1- and 2-propanol, and 2 commercially available hand disinfectants was examined at different concentrations, temperatures, and pH-values.

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Heterogeneity of COVID-19 manifestations in human population is vast, for reasons unknown. Cotton rats are a clinically relevant small animal model of human respiratory viral infections. Here, we demonstrate for the first time that SARS-CoV-2 infection in cotton rats affects multiple organs and systems, targeting species- and age-specific biological processes.

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Background: Oncogenic driver mutations in RAS/RAF oncogenes are frequent in colorectal cancer (CRC). The presence of different subclones within a single tumor can lead to treatment failure in anti-EGFR/epidermal growth factor receptor-directed antibody therapies. The identification of different subclones and their mutational profiles within a single tumor and the identification of morphologically distinct tumor areas might help to unravel novel aspects of tumor biology and therapy resistance.

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Corynebacterium glutamicum is the major host for the industrial production of amino acids and has become one of the best studied model organisms in microbial biotechnology. Rational strain construction has led to an improvement of producer strains and to a variety of novel producer strains with a broad substrate and product spectrum. A key factor for the success of these approaches is detailed knowledge of transcriptional regulation in C.

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Objective: The purpose of the present study is to investigate the inactivation of bioaerosols containing Bovine Coronavirus, BCoV, under repetitively pulsed radio frequency (RF) electromagnetic exposure.

Methods: These experiments were performed in a waveguide containing a flowing aerosol stream and were limited to a single RF waveform: ∼2 μs square envelope, 5.6 GHz, 4.

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Knowledge about the orientation of a representative ankle joint axis is limited to studies of tarsal morphology and of quasistatic movements. The aim of our study was therefore to determine the development of the axis orientation during walking. Intracortical bone pins were used to monitor the kinematics of the talus and tibia of five healthy volunteers.

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Overloading of tendon tissue may result in overuse tendon injuries in runners. One possible cause of overloading could be the occurrence of biomechanical inter-limb differences during running. However, scarce information exists concerning the simultaneous analysis of inter-limb differences in external and internal loading-related variables in habitual runners.

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Measuring the motion of the small foot bones is critical for understanding pathological loss of function. Biplanar videoradiography is well-suited to measure in vivo bone motion, but challenges arise when estimating the rotation and translation (pose) of each bone. The bone's pose is typically estimated with marker- or model-based methods.

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To date, there is no empirical evidence suggesting greater jump heights or cushioned landings when using figure skating (FS) blades of different mass and design. This study examined the effect of lightweight (Gold Seal Revolution from John Wilson) and traditional (Apex Supreme from Jackson Ultima and Volant from Riedell) blades, a new prototype blade with an integrated damping system (damping blade) in two different damping configurations, and running shoes (Runfalcon from Adidas) on kinetics and kinematics during simulated on-ice landings from 0.6 m and maximal countermovement jumps on synthetic ice, and measured dampening properties of the damping blade.

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In para-kayak, athletes with unilateral above knee amputation (AK) and athletes with below knee amputation (BK) compete in the same class. This has been questioned since previous research have shown that the legs are important for paddling performance. The purpose was therefore to examine differences in kinematic and kinetic performance variables between AK and BK para-kayak athletes and the amputated (A) and non-amputated (NA) sides.

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