Publications by authors named "Arnaud Jabet"

Article Synopsis
  • Ibrutinib, a first-generation BTK inhibitor, increases the risk of invasive fungal infections, while the second-generation BTK inhibitor, acalabrutinib, has unknown effects on neutrophil antifungal activity despite only a few reported cases of aspergillosis during its use.
  • Three new cases of invasive aspergillosis were identified in patients with chronic lymphocytic leukemia shortly after starting acalabrutinib therapy, raising concern about its impact on immune response.
  • After one month of acalabrutinib treatment, neutrophils exhibited a reduced ability to fight against Aspergillus fumigatus, highlighting the need for close monitoring of patients on this medication for potential fungal infections.
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Transmission of dermatophytes, especially Trichophyton mentagrophytes genotype VII, during sexual intercourse has been recently reported. We report 13 such cases in France. All patients were male; 12 were men who have sex with men.

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The increase in terbinafine resistance worldwide due to Trichophyton indotineae underlies the need for surveillance networks, deploying easy to perform methods to correctly identify resistant isolates and thereby reduce their spread. In the present study, we evaluated the performances of the terbinafine containing agar method (TCAM). Different technical parameters, such as culture medium (RPMI agar [RPMIA] or Sabouraud dextrose agar [SDA]) and inoculum size, were evaluated.

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Trichophyton indotineae is a newly described dermatophyte species. This fungal pathogen has recently emerged in India and is responsible for chronic or recurrent widespread superficial infections. Resistance to terbinafine is frequently associated to this pathogen and is related to point mutations in the gene encoding the squalene epoxidase.

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is an emerging pathogen which recently spread from India to Europe and that is more prone than other species of the complex to show resistance to terbinafine, resulting in the necessity of rapid identification. Here, we improved the online MSI-2 MALDI-TOF identification tool in order to identify . By multiplying the culture conditions (2 culture media and 6 stages of growth) prior to protein extractions for both test isolates and reference strains, we added 142 references corresponding to 12 strains inside the complex in the online MSI-2 database, of which 3 are strains.

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In recent years, we have moved from the sporadic description of terbinafine-resistant (TerR) spp. isolates to the Indian outbreak due to . Population flows have spread TerR worldwide, altering local epidemiology.

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Online MALDI-TOF mass spectrometry applications, such as MSI-2, have been shown to help identify dermatophytes, but recurrent errors are still observed between phylogenetically close species. The objective of this study was to assess different approaches to reduce the occurrence of such errors by adding new reference spectra to the MSI-2 application. Nine libraries were set up, comprising an increasing number of spectra obtained from reference strains that were submitted to various culture durations on two distinct culture media: Sabouraud gentamicin chloramphenicol medium and IDFP Conidia medium.

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Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France. Analysis of internal transcribed spacer sequences revealed the wide spread of this species in Asia and Europe. Detection of T.

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Nine new human invasive infections caused by the keratinophilic fungi Nannizziopsis obscura have been reported in France since 2004. The patients had variable clinical manifestations, had frequent dissemination, were mainly T-cell immunocompromised, and all originated from sub-Saharan West Africa. Before collection of the isolates, the etiologies of these infections were often misidentified, underscoring the extent of microscopic and cultural polymorphisms.

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