[F]-JK-PSMA-7 and [F]-FDG tumour PET uptake in treated xenograft human prostate cancer model in mice.

Purpose: This preclinical study aims to evaluate the extent to which a change in prostate-specific membrane antigen (PSMA) expression of castration-resistant prostate cancer (CRPC) following standard treatment is reflected in [F]JK-PSMA-7 PET/CT.

Methods: Castrated mice supplemented with testosterone implant were xenografted with human LNCaP CRPC. After appropriate tumour growth, androgen deprivation therapy (ADT) was carried out by the removal of the implant followed by a single injection of docetaxel (400 μg/20-g mouse) 2 weeks later.