Publications by authors named "Arnaud Gos"
The Gene Ontology (GO) knowledgebase (http://geneontology.org) is a comprehensive resource concerning the functions of genes and gene products (proteins and noncoding RNAs). GO annotations cover genes from organisms across the tree of life as well as viruses, though most gene function knowledge currently derives from experiments carried out in a relatively small number of model organisms.
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- High-quality bioinformatics resources are essential for analyzing patient-derived clinical samples, translating complex biological data from journal articles into structured formats for better accessibility and productivity in research.
- The objective of this study was to update key public-domain resources to enhance support for Alzheimer's disease research by collaborating with the clinical research community to identify important proteins.
- As a result, significant data updates were made across several databases, enhancing the understanding of Alzheimer's disease through improved protein entries, molecular interaction networks, and the availability of organized resources for researchers.
During the last few years, next-generation sequencing (NGS) technologies have accelerated the detection of genetic variants resulting in the rapid discovery of new disease-associated genes. However, the wealth of variation data made available by NGS alone is not sufficient to understand the mechanisms underlying disease pathogenesis and manifestation. Multidisciplinary approaches combining sequence and clinical data with prior biological knowledge are needed to unravel the role of genetic variants in human health and disease.
View Article and Find Full Text PDFThe GO annotation dataset provided by the UniProt Consortium (GOA: http://www.ebi.ac.
View Article and Find Full Text PDFUniProtKB/Swiss-Prot (http://beta.uniprot.org/uniprot; last accessed: 19 October 2007) is a manually curated knowledgebase providing information on protein sequences and functional annotation.
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