Publications by authors named "Arnaud Boureille"
Article Synopsis
- Capsule endoscopy (CE) is the leading technique for examining the small bowel, but analyzing the extensive video data, averaging 50,000 frames, can take 30 to 60 minutes per video.
- The CAD-CAP database was created from third-generation SB-CE videos collected from 12 French endoscopy centers to aid in developing computer-assisted diagnosis tools for this labor-intensive reading process.
- The database contains 4,174 SB-CE videos, with 1,480 showing pathological findings, leading to the extraction and categorization of over 5,000 frames of various lesions and 20,000 normal frames for training and validation of automated detection tools.
Background & Aims: Few data are available on the effects of tumor necrosis factor (TNF) antagonist therapy for patients with internal fistulizing Crohn's disease (CD) and there is debate regarding the risk of abscess. We aimed to assess the long-term efficacy and safety of anti-TNF therapy for patients with internal fistulas.
Methods: We performed a retrospective study of data collected from the Groupe d'Etude Thérapeutique des Affections Inflammatoires Digestives trial, from January 1, 2000, through December 31, 2017.
Background And Aim: Endoscopic assessment of mucosal healing in ulcerative colitis (UC) is increasingly accepted as a measure of disease activity, therapeutic goal, and the key prognostic indicator. While regular endoscopy evaluates appearance of the mucosal surface, confocal laser endomicroscopy (CLE) enables in vivo visualization of subepithelial mucosa at 1000× magnification during ongoing endoscopy. Our aims were to determine using CLE whether endoscopically normal appearing colonic mucosa in patients with UC in remission (UC-IR) has fully regenerated mucosal structures, resolved inflammation, and to identify the mechanisms.
View Article and Find Full Text PDFBackground: Cyclosporine A (CsA) is inconstantly effective in inducing remission in acute attacks of ulcerative colitis (UC) not responding to steroids. This study aimed to establish whether multidrug resistance gene (MDR)1 polymorphisms would be associated with CsA failure.
Patients And Methods: The distribution of the different genotypes of single nucleotide polymorphisms (SNP) G2677T/A and C3435T of MDR1 exons 21 and 26, respectively, was studied in 154 patients (mean age, 44 yr) who had received CsA to treat severe attacks of steroid resistant UC in 11 centers in France and Belgium.