Widespread EMR: a new technique for removal of large areas of mucosa.

Background: Widespread EMR is a novel technique for resection of large areas of mucosa as a single bloc. Large lesion size (>2 cm) is a recognized limitation of current EMR techniques. This study assessed the technical feasibility, efficacy, and safety of widespread EMR in a porcine model.

Future opportunities and developments for endoscopic gastroesophageal reflux disease therapy.

Endoscopic treatments for gastroesophageal reflux disease are directed at specific targets at the gastroesophageal junction. We explore the limitations and challenges of the anatomy, how current methods alter the anatomy and then speculate on the direction of future therapies.

Understanding endoluminal gastroplications: a histopathologic analysis of intraluminal suture plications.

Background: Endoluminal gastroplication is used to treat GERD, with modest results. Little is known of the histologic reaction to endosutures. Thus, the histologic response to intraluminal plications at different penetration depths within the gastric wall was studied in an animal model.

Hydroxypropyl methylcellulose: A better submucosal fluid cushion for endoscopic mucosal resection.

Background: Formation of a submucosal fluid cushion has become integral to endoscopic mucosal and polyp resection. Solutions available for injection into the submucosa of the GI tract create short-lasting submucosal fluid cushions or are costly. The feasibility, durability, and histologic response to submucosal fluid cushions created by injection of hydroxypropyl methylcellulose were studied in the esophagus of pigs.