A resetting particle embedded in a viscoelastic bath.

We examine the behavior of a colloidal particle immersed in a viscoelastic bath undergoing stochastic resetting at a rate r. Microscopic probes suspended in a viscoelastic environment do not follow the classical theory of Brownian motion. This is primarily because the memory from successive collisions between the medium particles and the probes does not necessarily decay instantly as opposed to the classical Langevin equation.

PADI4 expression in baseline circulating tumour cells acts as a prognostic biomarker in oral squamous cell carcinoma.

Oral Squamous Cell Carcinoma (OSCC), one of the most prevalent cancers in developing countries. It is associated with poor prognosis due to relapse in a significant number of patients. Circulating tumour cells (CTCs) are precursors for metastasis and thought to be key players in early relapse in various cancers including OSCC.

Drift-diffusive resetting search process with stochastic returns: Speedup beyond optimal instantaneous return.

Stochastic resetting has recently emerged as a proficient strategy to reduce the completion time for a broad class of first-passage processes. In the canonical setup, one intermittently resets a given system to its initial configuration only to start afresh and continue evolving in time until the target goal is met. This is, however, an instantaneous process and thus less feasible for any practical purposes.

Synthesis of shape-tunable PbZrTiO nanocrystals with lattice variations for piezoelectric energy harvesting and human motion detection.

PbZrTiO cubes with tunable sizes and cuboids have been hydrothermally synthesized. PbZrTiO cubes with three different Zr : Ti atomic percentages were also prepared. Analysis of synchrotron X-ray diffraction (XRD) patterns reveals the presence of two lattice components for these samples.

Metal-organic frameworks as thermocatalysts for hydrogen peroxide generation and environmental antibacterial applications.

Reactive oxygen species (ROS) are highly reactive, making them useful for environmental and health applications. Traditionally, photocatalysts and piezocatalysts have been used to generate ROS, but their utilization is limited by various environmental and physical constraints. This study introduces metal-organic frameworks (MOFs) as modern thermocatalysts efficiently producing hydrogen peroxide (HO) from small temperature differences.

Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population.

Introduction: Glomerular filtration rate (GFR) estimation equations have not been extensively validated in the Indian population. Preliminary data showed that the widely used creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 significantly overestimated GFR in Indians. Newer estimated GFR (eGFR) equations based on creatinine and cystatin C, omitting the race, have been recently proposed.

Active motion can be beneficial for target search with resetting in a thermal environment.

Stochastic resetting has recently emerged as an efficient target-searching strategy in various physical and biological systems. The efficiency of this strategy depends on the type of environmental noise, whether it is thermal or telegraphic (active). While the impact of each noise type on a search process has been investigated separately, their combined effects have not been explored.

Search with stochastic home returns can expedite classical first passage under resetting.

Classical first passage under resetting is a paradigm in the search process. Despite its multitude of applications across interdisciplinary sciences, experimental realizations of such resetting processes posit practical challenges in calibrating these zero time irreversible transitions. Here, we consider a strategy in which resetting is performed using finite-time return protocols in lieu of instantaneous returns.

Channel-facilitated transport under resetting dynamics.

The transport of particles through channels holds immense significance in physics, chemistry, and biological sciences. For instance, the motion of solutes through biological membranes is facilitated by specialized proteins that create water-filled channels. Valuable insights can be obtained by studying the transition paths of particles through a channel and gathering information on their lifetimes inside the channel as well as their exit probabilities.

Impact of a pilot mHealth intervention on treatment outcomes of TB patients seeking care in the private sector using Propensity Scores Matching-Evidence collated from New Delhi, India.

Mobile health applications called Digital Adherence Technologies (DATs), are increasingly used for improving treatment adherence among Tuberculosis patients to attain cure, and/or other chronic diseases requiring long-term and complex medication regimens. These DATs are found to be useful in resource-limited settings because of their cost efficiency in reaching out to vulnerable groups (providing pill and clinic visit reminders, relevant health information, and motivational messages) or those staying in remote or rural areas. Despite their growing ubiquity, there is very limited evidence on how DATs improve healthcare outcomes.

Neonatal CSF glucose measured by blood gas analyzer, glucometer, and standard laboratory methods.

Objective: To determine agreement between neonatal cerebrospinal fluid (CSF) glucose measured by standard laboratory method versus blood gas analyzers (BGA) and glucometers.

Study Design: This prospective, observational, cross-sectional study was conducted in a level III neonatal unit on 97 neonates undergoing lumbar puncture. Agreement was estimated by Lin's coefficient of concordance and Bland-Altman plot.

Effect of Fluid Therapy on Acid-Base Balance in Patients Undergoing Clipping for Ruptured Intracranial Aneurysm: A Prospective Randomized Controlled Trial.

 Neurosurgical patients often receive 0.9% normal saline (NS) during the perioperative period. Theoretically, a balanced salt solution (BSS) is better than 0.

Recent advances in minimally invasive biomarkers of OSCC: from generalized to personalized approach.

Oral cancer is the 6th most common type of cancer worldwide, and oral squamous cell carcinoma (OSCC) accounts for >90% of oral cancers. It is a major health problem, particularly in low- and middle-income countries (LMICs), due to both its high incidence and significant mortality and morbidity. Despite being a global burden, and even with the significant advancement in the management of OSCC, the overall outcome of the disease is still abysmal.

Programming tunable active dynamics in a self-propelled robot.

We present a scheme for producing tunable active dynamics in a self-propelled robotic device. The robot moves using the differential drive mechanism where two wheels can vary their instantaneous velocities independently. These velocities are calculated by equating robot's equations of motion in two dimensions with well-established active particle models and encoded into the robot's microcontroller.

Innate and adaptive immune responses in subjects with CPA secondary to post-pulmonary tuberculosis lung abnormalities.

Background: Post-tuberculosis lung abnormality (PTLA) is the most common risk factor for chronic pulmonary aspergillosis (CPA), and 14%-25% of the subjects with PTLA develop CPA. The pathogenesis and the host immune response in subjects with PTLA who develop CPA need to be better understood.

Methods: We prospectively compared the innate and adaptive immune responses mounted by patients of PTLA with or without CPA (controls).

A multicentre, double-blind, placebo-controlled randomized trial of Mycobacterium w in critically ill patients with COVID-19 (ARMY-2).

Background: Mycobacterium w (Mw), an immunomodulator, resulted in better clinical status in severe coronavirus infectious disease 19 (COVID-19) but no survival benefit in a previous study. Herein, we investigate whether Mw could improve clinical outcomes and survival in COVID-19.

Materials And Methods: In a multicentric, randomized, double-blind, parallel-group, placebo-controlled trial, we randomized hospitalized subjects with severe COVID-19 to receive either 0.

An ultra energy-efficient hardware platform for neuromorphic computing enabled by 2D-TMD tunnel-FETs.

Brain-like energy-efficient computing has remained elusive for neuromorphic (NM) circuits and hardware platform implementations despite decades of research. In this work we reveal the opportunity to significantly improve the energy efficiency of digital neuromorphic hardware by introducing NM circuits employing two-dimensional (2D) transition metal dichalcogenide (TMD) layered channel material-based tunnel-field-effect transistors (TFETs). Our novel leaky-integrate-fire (LIF) based digital NM circuit along with its Hebbian learning circuitry operates at a wide range of supply voltages, frequencies, and activity factors, enabling two orders of magnitude higher energy-efficient computing that is difficult to achieve with conventional material and/or device platforms, specifically the silicon-based 7 nm low-standby-power FinFET technology.

Arrhenius law for interacting diffusive systems.

Finding the mean time it takes for a particle to escape from a metastable state due to thermal fluctuations is a fundamental problem in physics, chemistry, and biology. Here, we consider the escape rate of interacting diffusive particles, from a deep potential trap within the framework of the macroscopic fluctuation theory-a nonequilibrium hydrodynamic theory. For systems without excluded volume, our investigation reveals adherence to the well-established Arrhenius law.

Emerging universality classes in thermally assisted activation of interacting diffusive systems: A perturbative hydrodynamic approach.

Thermal activation of a particle from a deep potential trap follows the Arrhenius law. Recently, this result has been generalized for interacting diffusive particles in the trap, revealing two universality classes-the Arrhenius class and the excluded volume class. The result was demonstrated with the aid of numerical analysis.

Role of in Acne and Effect of Isotretinoin on Expression.

Background: Nodulocystic acne is a severe type of acne that is known to improve after treatment with isotretinoin. Melnik has hypothesized a unifying concept on the mechanism of acne pathogenesis involving altered expression of Forkhead box O transcription factor () and role of isotretinoin in improving acne via modulating this pathway.

Aim: To evaluate the pathway proposed by Melnik in acne pathogenesis by analysing the difference in the expression of , peroxisome proliferator-activated receptor (), and androgen receptor (AR) between acne patients and non-acne controls and the effect of treatment with isotretinoin on change in expression of these genes in acne patients.

Operational priorities for engaging with India's private healthcare sector for the control of tuberculosis: a modelling study.

Objectives: To estimate the potential impact of expanding services offered by the Joint Effort for Elimination of Tuberculosis (JEET), the largest private sector engagement initiative for tuberculosis (TB) in India.

Design: We developed a mathematical model of TB transmission dynamics, coupled with a cost model.

Setting: Ahmedabad and New Delhi, two cities with contrasting levels of JEET coverage.

Estimation of dietary intake of sodium, potassium, phosphorus and protein in healthy Indian population and patients with chronic kidney disease.

Introduction: Poor nutritious diet is a major risk element for non-communicable diseases (NCD), which are of considerable public health concern. Given the diverse dietary patterns in India, precise determination of nutrient consumption is crucial for disease management. The present study assessed the dietary intake of sodium, potassium, protein, and phosphorus among North Indians.

A FACS-based novel isolation technique identifies heterogeneous CTCs in oral squamous cell carcinoma.

Purpose: Isolating circulating tumour cells (CTCs) from the blood is challenging due to their low abundance and heterogeneity. Limitations of conventional CTC detection methods highlight the need for improved strategies to detect and isolate CTCs. Currently, the Food and Drug Administration (FDA)-approved CellSearch™ and other RUO techniques are not available in India.