Bioactive ECM-mimicking nerve guidance conduit for enhancing peripheral nerve repair.

Extensive research efforts are being directed towards identifying alternatives to autografts for the treatment of peripheral nerve injuries (PNIs) with engineered nerve conduits (NGCs) identified as having potential for PNI patients. These NGCs, however, may not fulfill the necessary criteria for a successful transplant, such as sufficient mechanical structural support and functionalization. To address the aforementioned limitations of NGCs, the present investigation explored the development of double cross-linked hydrogels (o-CSMA-E) that integrate the biocompatibility of porcine tendon extracellular matrix (ECM) with the antimicrobial and conductive properties of methacrylated quaternary chitosan.

Platelet Membrane-Camouflaged Copper Doped CaO Biomimetic Nanomedicines for Breast Cancer Combination Treatment.

Breast cancer (BC) is the most frequently diagnosed cancer in women worldwide. Chemodynamic therapy (CDT), photothermal therapy (PTT), and ion interference therapy (IIT), used in combination, represent a common treatment. In this study, platelet membrane-camouflaged copper-doped CaO biomimetic nanomedicines have been developed for breast cancer treatments.

Fabrication and Properties of Hydrogel Dressings Based on Genipin Crosslinked Chondroitin Sulfate and Chitosan.

Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and H nuclear magnetic resonance (H NMR) spectroscopy.

Fabrication of injectable, adhesive, self-healing, superabsorbent hydrogels based on quaternary ammonium chitosan and oxidized pullulan.

Injectable hydrogels, which are polymeric materials that are characterized by their ability to be injected in a liquid form into cavities and subsequently undergo in situ solidification, have garnered significant attention. These materials are extensively used in a range of biomedical applications. This study synthesized several injectable composite hydrogels through the mild Schiff base reaction while imposing different concentrations of quaternary ammonium chitosan and oxidized pullulan.

Eco-Friendly Carbon Nanotubes Reinforced with Sodium Alginate/Polyacrylic Acid for Enhanced Adsorption of Copper Ions: Kinetics, Isotherm, and Mechanism Adsorption Studies.

This study investigates the removal efficiency of Cu from wastewater using a composite hydrogel made of carbon nanotubes (CNTs), sodium alginate (SA), and polyacrylic acid (PAA) prepared by free radical polymerization. The CNTs@SA/PAA hydrogel's structure and properties were characterized using SEM, TEM, FTIR, XRD, rheology, DSC, EDS, elemental mapping analysis, and swelling. The adsorption performance for Cu was tested in batch adsorption experiments, considering the pH, dosage, initial concentration, and contact time.

Hyaluronic Acid Role in Biomaterials Prevascularization.

Tissue vascularization is a major bottleneck in tissue engineering. In this review, the state of the art on the intricate role of hyaluronic acid (HA) in angiogenesis is explored. HA plays a twofold role in angiogenesis.

Phloridzin functionalized gelatin-based scaffold for bone tissue engineering.

Polyphenol-functionalized biomaterials are significant in the field of bone tissue engineering (BTE) due to their antioxidant, anti-inflammatory, and osteoinductive properties. In this study, a gelatin (Gel)-based scaffold was functionalized with phloridzin (Ph), the primary polyphenol in apple by-products, to investigate its influence on physicochemical and morphological, properties of the scaffold for BTE application. A preliminary assessment of the biological properties of the functionalized scaffold was also undertaken.