Studies on solubility measurement of codeine phosphate (pain reliever drug) in supercritical carbon dioxide and modeling.

In this study, the solubilities of codeine phosphate, a widely used pain reliever, in supercritical carbon dioxide (SC-CO) were measured under various pressures and temperature conditions. The lowest determined mole fraction of codeine phosphate in SC-CO was 1.297 × 10 at 308 K and 12 MPa, while the highest was 6.

Experimental solubility and modeling of Crizotinib (anti-cancer medication) in supercritical carbon dioxide.

Measurement of saturation solubility of drugs in a supercritical fluid is an important parameter for the implementation of supercritical technology in pharmaceutical industry. CO is the most sorted substance as a supercritical fluid since it has attractive properties like easily achievable critical temperature, moderate pressure. Cancer is increasingly affecting the mankind, a proper dosage while treating would help in minimizing the drug usage.