Lupeol acetate isolated from L. fruit as a template for the synthesis of -alkyl-arylsulfonamide derivatives and their synergistic effects with metronidazole against .

Pentacyclic triterpenes are found in a great variety of natural products and constitute an organic template for the development of new derivative compounds with therapeutic applications. In the present work, lupeol acetate isolated from L. fruit was used as a template for the synthesis of novel -alkyl-arylsulfonamide derivatives, and their synergistic effects with metronidazole against strains of were tested.