Dynamic Control of Mitochondrial Ca Levels as a Survival Strategy of Cancer Cells.

Cancer cells have increased energy requirements due to their enhanced proliferation activity. This energy demand is, among others, met by mitochondrial ATP production. Since the second messenger Ca maintains the activity of Krebs cycle dehydrogenases that fuel mitochondrial respiration, proper mitochondrial Ca uptake is crucial for a cancer cell survival.

Accuracy assessment of 3D-printed tooth replicas.

Aim: The production of individual tooth replicas has two applications in dental practice: tooth autotransplantations and dental root analogue implants. These applications require a particularly high degree of precision. The purpose of this study was to establish and evaluate a method for fabricating individual 3D-printed tooth replicas.

Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction.

Senescence is related to the loss of cellular homeostasis and functions, which leads to a progressive decline in physiological ability and to aging-associated diseases. Since mitochondria are essential to energy supply, cell differentiation, cell cycle control, intracellular signaling and Ca sequestration, fine-tuning mitochondrial activity appropriately, is a tightrope walk during aging. For instance, the mitochondrial oxidative phosphorylation (OXPHOS) ensures a supply of adenosine triphosphate (ATP), but is also the main source of potentially harmful levels of reactive oxygen species (ROS).

UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients.

Cancer cells have developed unique strategies to meet their high energy demand. Therefore, they have established a setting of Ca-triggered high mitochondrial activity. But mitochondrial Ca uptake has to be strictly controlled to avoid mitochondrial Ca overload that would cause apoptotic cell death.

Dosis Facit Sanitatem-Concentration-Dependent Effects of Resveratrol on Mitochondria.

The naturally occurring polyphenol, resveratrol (RSV), is known for a broad range of actions. These include a positive impact on lifespan and health, but also pro-apoptotic anti-cancer properties. Interestingly, cell culture experiments have revealed a strong impact of RSV on mitochondrial function.