Hemorrhagic changes and microglia activation induced by venom with the inhibited enzymatic activity in rat brain.

The metalloproteinases and phospholipase A are the main enzymes in the venom of that play a decisive role in the destructive and toxic effects on the organism of the prey. Metalloproteinases cause hemorrhagic damage, destroy the basement membrane of the blood vessel and disrupt the connections between endothelial cells. Phospholipase A2 causes hemolysis of erythrocytes, destroy the cell membranes, and inhibits the adhesion of platelets and so on.