Publications by authors named "Armelle Garenne"
Article Synopsis
- About 20% of neonates with congenital cytomegalovirus (cCMV) experience long-term health issues, making early prediction of outcomes crucial for treatment and counseling.
- The study followed 227 neonates diagnosed with cCMV to identify predictive markers; key findings showed maternal primary infection during the first trimester greatly increased the risk of negative outcomes.
- A model using normal hearing, platelet count, and cranial ultrasound at birth showed high specificity and can help clinicians tailor care for cCMV-affected neonates.
Clinical Value of Serial Quantitative Analysis of Cytomegalovirus DNA in Blood and Saliva Over the First 24 Months of Life in Congenital Infection: The French Cymepedia Cohort.
J Pediatr
February 2023
Objective: To evaluate cytomegalovirus (CMV) viral load dynamics in blood and saliva during the first 2 years of life in symptomatic and asymptomatic infected infants and to identify whether these kinetics could have practical clinical implications.
Study Design: The Cymepedia cohort prospectively included 256 congenitally infected neonates followed for 2 years. Whole blood and saliva were collected at inclusion and months 4 and 12, and saliva at months 18 and 24.
Article Synopsis
- - Mitochondrial complex V is crucial for ATP production, with most of its subunits encoded by nuclear genes; a specific splice variant (c.87+3A>G) in the ATP5PO gene was found in three individuals suspected of having a mitochondrial disorder.
- - The affected individuals exhibited severe symptoms typical of Leigh syndrome, including developmental issues and cardiomyopathy, and biochemical studies revealed a significant reduction in ATP5PO protein levels and impaired complex V function.
- - Experimental results indicated that the ATP5PO variant leads to a non-functional protein due to the skipping of an essential exon, confirming its pathogenic role and linking it to defects in mitochondrial energy production.
Background: The known relationship between the gestational age at maternal primary infection an the outcome of congenital CMV is based on small, retrospective studies conducted between 1980 and 2011. They reported that 32% and 15% of cases had sequelae following a maternal primary infection in the first and second or the third trimester, respectively. We aimed to revisit this relationship prospectively between 2011 and 2017, using accurate virological tools.
View Article and Find Full Text PDFObjective: To evaluate the status of congenital diaphragmatic hernia (CDH) management in France and to assess predictors of adverse outcomes.
Study Design: We reviewed the first-year outcome of all cases of CDH reported to the French National Register in 2011.
Results: A total of 158 cases were included.
Infants born preterm are at a higher risk of complications and hospitalization in cases of rotavirus diarrhea than children born at term. We evaluated the impact of a rotavirus vaccination campaign (May 2007 to May 2010) on hospitalizations for rotavirus gastroenteritis in a population of children under 3 years old born prematurely (before 37 weeks of gestation) in the Brest University Hospital birth zone. Active surveillance from 2002 to 2006 and a prospective collection of hospitalizations for rotavirus diarrhea were initiated in the pediatric units of Brest University Hospital until May 2010.
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