Enzyme_Metal-Organic Framework Composites as Novel Approach for Microplastic Degradation.

Plastic pollution is one of the main worldwide environmental concerns. Our lifestyle involves persistent plastic consumption, aggravating the low efficiency of wastewater treatment plants in its removal. Nano/microplastics are accumulated in living beings, pushing to identify new water remediation strategies to avoid their harmful effects.

Use of the PARO robot as a social mediator in a sample of children with neurodevelopmental disorders and typical development.

Background: Social robotics is a research field aimed at providing robots with skills related to social behavior and natural human interaction. Many studies have demonstrated the efficacy of these robots as socio-communicative mediators. Others have used them to create a new communication channel and promote social interaction in chil-dren with autism spectrum disorder (ASD).

Psychometric Properties of the Perinatal Anxiety Screening Scale Administered to Italian Women in the Perinatal Period.

Literature stressed the importance of using valid, reliable measures to assess anxiety in the perinatal period, like the self-rated Perinatal Anxiety Screening Scale (PASS). We aimed to examine the psychometric properties of the Italian PASS version in a sample of Italian women undergoing mental health screening during their third trimester of pregnancy and its diagnostic accuracy in a control perinatal sample of psychiatric outpatients. Sample comprised 289 women aged 33.

The heterogeneity of cancer endothelium: The relevance of angiogenesis and endothelial progenitor cells in cancer microenvironment.

Tumor-associated vessels constitution is the result of angiogenesis, the hallmark of cancer essential for tumor to develop in dimension and to spread throughout the organism. Tumor endothelium is configured as an active functioning organ capable of determine interaction with the immune response and all the other components of the variegate cancer microenvironment, determining reciprocal influence. Angiogenesis is here analyzed in its molecular and cellular mechanisms, multiple mediators and principal players, represented by Endothelial Cells.

Blood and lymphatic vessels contribute to the impact of the immune microenvironment on clinical outcome in non-small-cell lung cancer.

Objectives: Lymphangiogenesis plays a critical role in the immune response, tumour progression and therapy effectiveness. The aim of this study was to determine whether the interplay between the lymphatic and the blood microvasculature, tumour-infiltrating lymphocytes and the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint constitutes an immune microenvironment affecting the clinical outcome of patients with non-small-cell lung cancer.

Methods: Samples from 50 squamous cell carcinomas and 42 adenocarcinomas were subjected to immunofluorescence to detect blood and lymphatic vessels.

Low PD-1 Expression in Cytotoxic CD8 Tumor-Infiltrating Lymphocytes Confers an Immune-Privileged Tissue Microenvironment in NSCLC with a Prognostic and Predictive Value.

The success of immune checkpoint inhibitors strengthens the notion that tumor growth and regression are immune regulated. To determine whether distinct tissue immune microenvironments differentially affect clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis of PD-L1 and tumor-infiltrating lymphocytes (TIL) was performed. Samples from resected adenocarcinoma (ADC 42), squamous cell carcinoma (SCC 58), and 26 advanced diseases (13 ADC and 13 SCC) treated with nivolumab were analyzed.

Exploring variables associated with rehabilitation length of stay in brain injuries patients.

Background: The impact of outcome measure as early variables on rehabilitation length of stay (LOS) in traumatic brain injury (TBI) patients remains poorly investigated.

Aim: To investigate: 1) the association between LOS and motor and functional outcomes; 2) the predictive factors of LOS in TBI patients admitted to a rehabilitation center.

Design: Retrospective study.

Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones investigated as antimicrobial agents.

Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones and assay of their antibacterial and antifungal activity are reported. Compounds 3a-e,g were prepared by reaction of substituted 2-chloromethyl-4H-pyrido[1,2-a]pyrimidin-4-ones 2a-c with suitable amines. These compounds and the previously obtained analogues 5a-o and 6a,b have been tested for their antimicrobial activity.

Bacterial species detected in some bottled mineral waters sold in Italy.

A total of 51 samples from 32 different kinds of mineral water were examined to investigate their microbial facies in view of a possible relationship with ionic composition. No difference was found between mineral and oligomineral waters. The genera most represented were Pseudomonas, Flavobacterium and Alcaligenes; only rarely could members of these genera be assigned precisely to a defined species, because many strains showed intermediate patterns.

Search for acid-fast bacilli in bottled mineral waters.

Samples of bottled mineral water sold in Italy in accordance with the law on microbiological standards were examined for the presence of acid-fast bacilli. Eighty-four samples were tested, 11 with added carbon dioxide and 73 without. Acid-fast bacilli were found in 1 of the former samples and in 8 of the latter, a total of 10.

[Epidemiological remarks on the "S. Arizonae" strains isolated from various animals in tuscany during 1969-1978 (author's transl)].

After a review of the taxonomic history of the genus Arizona culminated in the insertion of these bacteria in the Kauffmann-White schema, the most significant references concerning their pathogenicity and occurrence are related. In this paper, the outbreaks and sporadic cases by S. arizonae which occurred in Tuscan area during 1969-1978 are reported; between several animal species, turkeys were found frequently infect and the same serotype (S.

[Serological recognition of agglutinins against O and H antigens of various Salmonellae in "normal" adult subjects].

The distribution of Salmonella agglutinins among 390 normal sera from people living in the district of Pisa is described, and the relation of these findings with the Salmonella serotypes occurring in the same area is discussed. Clusters of agglutinins for several O and H antigens were found at or above a titre of 1:20, in many samples. In order to explain the significance of such antibodies and their origin an identical survey was carried out on some sera from patients with chronic liver disease, using the same antigens suspensions.

["S. wien" and "S. bredeney" plasmidic resistance to disinfectant agents and antibiotics (author's transl)].

Several antiseptic and disinfectant compounds have been investigated for their minimal inhibitory concentration (MIC) against antibiotic multiresistant strains of S. wien and S. bredeney as well as S.

[Drug resistance of Shigella strains isolated in Central Italy during 1969-1976 (author's transl)].

Only ninety-three strains of Shigella, eightyseven of which have been identified as S. sonnei and six as S. flexneri were collected during 1969-1976 at the Pathogen Enterobacteria Centre of Pisa in Central Italy, as evidence of an epidemiological situation marked by a rare occurrence of syndromes related to these organisms.

[Research methods of R factors (author's transl)].

After having outlined the routine methods for the study of drug resistance plasmids used at highly specialized centres such as the London Enteric Reference Laboratory, the AA. examine the most practical methods of a pure and simple way of discovering R factors in enterobacteria. A brief reference is made to some of the in vivo transfer techniques before reducing the various possibilities of in vitro survey to essentials.

[Control of the technic for recovery of E coli K12 after acquisition of R factors. Tests with various culture substrates under different mating conditions].

A survey was carried out in order to ascertain the reliable conditions for the recovery of E. coli K12 after acquisition of extrachromosomial resistance from polyresistant strains of Salmonella bredeney, responsible for a hospital outbreak of gastroenteritis. In particular in this study the length of mating, the amounts of partners in the cross-cultures, the availability of different media for selection of recipient E.

[Polyresistant "Salmonella bredeney" in a general surgical ward (author's transl)].

A series of cases of postoperative gastroenteritis by Salmonella bredeney in a general surgical ward has been described. The particular serotype of Salmonella in question, the widerange of drug-resistance of the strains, the epidemiological stages of the outbreak and the kind of the ward interested have been considered of uncommon occurrence.