Publications by authors named "Armando de Una-Flores"
Multidrug resistance (MDR) commonly leads to cancer treatment failure because cancer cells often expel chemotherapeutic drugs using ATP-binding cassette (ABC) transporters, which reduce drug levels within the cells. This study investigated the clinical characteristics and single nucleotide variant (SNV) in , , , , and , and their association with mortality in pediatric patients with central nervous system tumors (CNST). Using TaqMan probes, a real-time polymerase chain reaction genotyped 15 SNPs in 111 samples.
View Article and Find Full Text PDFChanges in the neutrophil to lymphocyte ratio as predictors of outcome in pediatric patients with central nervous system tumors undergoing surgical resection.
Cancer Biomark
April 2022
Background: Changes in neutrophil to lymphocyte ratio (ΔNLR) have been used as a clinical tool for stratification and prognosis of patients with solid tumors, there is scarce evidence of their clinical relevance in patients with tumors of the central nervous system who have also undergone surgical resection.
Objective: Determine if (ΔNLR) are associated with poor response to treatment and worse prognosis in pediatric patients with central nervous system tumors (CNST) who underwent surgical resection.
Methods: We performed a retrospective cohort study; demographic, clinical, and hematological variables were evaluated, Kaplan-Meier survival curves and Cox proportional hazards regression model were performed to evaluate prognosis.
Ifosfamide (IFA) is an effective antineoplastic for solid tumours in children, although it is associated with high levels of systemic toxicity and causes death in some cases. The aim of this study was to determine whether the presence of certain allelic variants of genes , , and increases the risk of toxicity in children with solid tumours treated with ifosfamide. A total of 131 DNA samples were genotyped by real-time polymerase chain reaction (RT-PCR) using TaqMan probes.
View Article and Find Full Text PDFArticle Synopsis
- The CYP450 complex is involved in the metabolism of ifosfamide, a drug for treating solid tumors, and genetic variations, particularly SNPs, impact enzyme activity.
- A study analyzed 148 DNA samples from children using real-time PCR to compare ifosfamide levels and the effects of specific gene variants on treatment outcomes.
- Results showed that certain genotypes were linked to higher or lower levels of ifosfamide, with a specific variant correlating to a poorer response to treatment.