Publications by authors named "Armando Perez De Prado"
Corrigendum to "Comparative evaluation of local and downstream responses in two commercially available paclitaxel-coated balloons in healthy peripheral arteries of a swine model".
María Gracia de Garnica García Laura Mola Mola Solà Claudia Pérez-Martínez Luis Duocastella Codina María Molina Crisol Armando Pérez de Prado
Cardiovasc Pathol
December 2024
Background: Stent underexpansion is a significant challenge in percutaneous coronary intervention, critically impacting patient outcomes. While excimer laser coronary angioplasty (ELCA) and intravascular lithotripsy (IVL) are increasingly used to address this issue, their full impact on the integrity of drug-eluting stents remains unclear, raising concerns about their safety and efficacy.
Methods: This in vitro study assessed the effects of ELCA and IVL on the structural integrity of drug-eluting stents using scanning electron microscopy.
Article Synopsis
- A study evaluated the effectiveness of closing a patent foramen ovale (PFO) after a cryptogenic stroke, comparing those who had it done within 9 months (early closure) to those who had it done after 9 months (delayed closure).
- The research found no significant differences in recurrence rates of cerebrovascular events or systemic embolisms between the early and delayed closure groups, indicating similar outcomes regardless of when the procedure was performed.
- The results suggest that PFO closure might be beneficial even in patients with a cryptogenic event that occurred more than 9 months ago, challenging the notion that the timing of the closure is critical.
Angiographic and Histopathological Characteristics of a Novel Polyacrylate Liquid Embolic Agent Compared with Ethylene-Vinyl Alcohol Copolymer in a Large Animal Model.
María Gracia de Garnica García Sofía Valle Iglesias Claudia Pérez-Martínez Fernando Gómez Muñoz Antonio López-Rueda Armando Pérez de Prado
J Vasc Interv Radiol
January 2025
Purpose: To study the in vivo safety and effectiveness of a novel radiopaque nonadhesive polyacrylate (PA) peripheral liquid embolic system (AMBER SEL-P) relative to ethylene-vinyl alcohol copolymer (EVOH, Onyx) in a healthy swine endovascular model.
Materials And Methods: Twenty-five swine underwent rete mirabile and bilateral kidney embolization with PA or EVOH and were followed up for 24 hours (n = 5) and 30 days (n = 10), and 3 (n = 10) months. Angiographic features (penetrability, radiopacity, catheter entrapment, fragmentation, occlusion, and vasospasm) were evaluated.
Article Synopsis
- Patients with a heart condition called atrial fibrillation (AF) who have strokes can still be at very high risk of having more strokes, even when taking medication to prevent them.
- Left atrial appendage occlusion (LAAO) is a special procedure aimed at helping these patients avoid future strokes.
- A study compared two groups – one that had LAAO and one that only continued their usual medication – and found that there was still a risk of strokes in both groups over a two-year period.
Article Synopsis
- The article reviews the 2023 activity report from the Interventional Cardiology Association of the Spanish Society of Cardiology, highlighting key trends in interventional cardiology practices in Spain.
- A survey involving 119 hospitals revealed a slight decrease in diagnostic studies but an increase in percutaneous coronary interventions (PCI), with a notable rise in the use of drug-coated balloons and techniques for plaque modification.
- The findings indicate a stabilization in coronary interventions while showcasing a growth in complex procedures, particularly for valvular and nonvalvular structural heart diseases, with primary PCI becoming the leading treatment for myocardial infarction.
Comparative evaluation of local and downstream responses in two commercially available paclitaxel-coated balloons in healthy peripheral arteries of a swine model.
María Gracia de Garnica García Laura Mola Solà Claudia Pérez-Martínez Luis Duocastella Codina María Molina Crisol Armando Pérez de Prado
Cardiovasc Pathol
November 2024
Objective: To investigate the local, downstream, and systemic effects of 2 different paclitaxel-coated balloons.
Design: Preclinical study in healthy peripheral arteries of a swine model, with randomized allocation of the distribution of the devices: the test paclitaxel-coated balloon (PCB) (Luminor), a control PCB (IN.PACT), and a plain angioplasty balloon (Oceanus), considering single (1×) and overlapping (3×) doses with simple blind histologic analysis.
Background: In patients with in-stent restenosis (ISR) bioresorbable vascular scaffolds (BVS) provide similar results to drug-coated balloons (DCBs) but are inferior to drug-eluting stents (DES) at 1 year. However, the long-term efficacy of BVS in these patients remains unknown.
Objectives: This study sought to assess the long-term safety and efficacy of BVS in patients with ISR.
Article Synopsis
- - The study investigated the effectiveness of using a SyncVision/iFR (S-iFR)-guided strategy for percutaneous coronary intervention (PCI) in patients with complex coronary lesions, compared to a standard angiography-guided approach.
- - 100 patients were randomized into two groups: one using S-iFR guidance and the other using angiography; the main focus was on the implanted stent length and target vessel failure (TVF) after one year.
- - Results showed that the S-iFR group had a shorter total stent length but also a slight increase in TVF, although this increase was not statistically significant.
Article Synopsis
- Left atrial appendage occlusion (LAAO) is a treatment for patients with atrial fibrillation (AF) who can't use oral anticoagulation therapy (OAT) and those who face recurring thrombotic events despite OAT.
- This study compared the efficacy of LAAO in patients experiencing thrombotic events while on OAT against those who had contraindications for OAT, using data from a large registry and propensity score matching for accuracy.
- Results showed no significant difference in ischemic stroke rates between the two groups, but the LAAO patients on OAT had a higher thromboembolic risk but lower bleeding risk, suggesting LAAO is a viable option for these patients.
Article Synopsis
- Intravascular lithotripsy (IVL) is a new technique aimed at improving stenting in patients with coronary calcification, which can hinder optimal results.
- A multicenter study analyzed 90 patients with both concentric and eccentric calcium morphologies to determine IVL's efficacy, focusing on outcomes such as angiographic success and fracture presence post-procedure.
- Results showed that while concentric lesions had more fractures, overall effectiveness in terms of stent expansion and lumen area was not significantly different between the two types of calcium morphology.
Applications of three-dimensional printing in percutaneous closure of aortic-to-right ventricle fistula after transcatheter aortic valve replacement: a case report.
Julio Echarte-Morales Irene Toribio-García Alfredo Redondo Diéguez Armando Pérez de Prado Felipe Fernández-Vázquez
Eur Heart J Case Rep
May 2024
Background: Percutaneous closure of aortic-to-right ventricle (ARV) fistula has emerged as an alternative to surgical management in selected cases. The use of three-dimensional (3D) printing in interventional planning for structural heart disease provides a concrete understanding, and it is useful in diagnostic assessment and to guide treatment approaches and to simulate procedures.
Case Summary: We report a case of a 70-year-old male presenting in cardiogenic shock due to severe aortic stenosis and reduced left ventricular ejection fraction.
Article Synopsis
- Intravascular lithotripsy (IVL) is effective for treating calcified coronary lesions in patients with stable coronary disease, as shown in a study involving 426 patients across 26 centers in Spain.
- The study found that IVL was successfully delivered in 99% of cases, achieving procedural success in 66% of patients and similar outcomes for both acute coronary syndrome (ACS) and chronic coronary syndrome (CCS) groups.
- The safety analysis showed a relatively low rate of major adverse cardiovascular events (MACE) at 30 days, with 3% overall (1% for CCS and 5% for ACS), indicating that IVL is both safe and effective in real-life clinical settings.
Article Synopsis
- A study found that using Quantitative Flow Ratio (QFR) for virtual angioplasty before and after PCI (Percutaneous Coronary Intervention) led to better outcomes than traditional angiographic methods, but there is a lack of correlation between pre-PCI QFR and post-PCI FFR (Fractional Flow Reserve).
- The study involved 84 patients with significant coronary lesions, focusing on measuring various flow ratios before and after the procedure, with an average age of 65.5 years and a majority having lesions in the left anterior descending artery.
- Despite achieving procedural success and improvements in post-PCI FFR, the pre-PCI QFR did not show reliable correlation with the post-PCI FFR, indicating
Article Synopsis
- This study investigates device-related thrombus (DRT) occurrences after left atrial appendage closure (LAAC), focusing on how often it persists or recurs.
- It found that about 29% of DRT cases persist, with being female and having a larger initial thrombus size being significant predictors.
- Unfavorable DRT evolution is linked to a higher rate of thromboembolic events, emphasizing the importance of monitoring thrombus size post-LAAC.
Article Synopsis
- This article reports on the annual activities of the Interventional Cardiology Association of the Spanish Society of Cardiology for 2022.
- A total of 111 centers participated, revealing a 4.8% increase in diagnostic studies and a significant 22% rise in PCIs on the left main coronary artery, while the overall PCI numbers remained stable.
- Key trends included a preference for the radial approach in 94.9% of cases, increased use of drug-eluting balloons and intracoronary imaging, and a continuous rise in noncoronary procedures, especially those related to heart valve and structural heart issues.
Changes in the Treatment Strategy Following Intracoronary Pressure Wire in a Contemporaneous Real-Life Cohort of Patients With Intermediate Coronary Stenosis. Results From a Nationwide Registry.
Oriol Rodriguez-Leor Beatriz Toledano Ramón López-Palop Fernando Rivero Salvatore Brugaletta Armando Pérez de Prado
Cardiovasc Revasc Med
June 2023
Article Synopsis
- The study focused on the use of intracoronary pressure wires in guiding treatment for patients with coronary artery disease, aiming to assess changes in diagnosis, treatment strategies, and clinical outcomes.
- Involving 1,414 patients and observing 1,781 lesions, the study found significant changes in the extent of coronary disease and treatment plans, with over half of the patients experiencing adjustments after using the pressure wire.
- The findings indicated that using the pressure wire was generally safe and led to a lower incidence of major adverse cardiovascular events (MACE), particularly when percutaneous coronary intervention (PCI) was the initial treatment strategy.
Article Synopsis
- Patients with spontaneous coronary artery dissection (SCAD) who presented as ST-segment-elevation myocardial infarction (STEMI) exhibited more severe coronary lesions and worse blood flow compared to those presenting as non-ST-segment elevation myocardial infarction (NSTEMI).
- During treatment, STEMI patients were more frequently treated with percutaneous coronary intervention (PCI) and had higher rates of left ventricular systolic dysfunction, but both groups had similar rates of major adverse events during hospital admission.
- In the long term, despite the initial differences in severity and treatment, both STEMI and NSTEMI SCAD patients had comparable outcomes concerning major adverse cardiac and cerebrovascular events.
Instantaneous Wave-Free Ratio for the Assessment of Intermediate Left Main Coronary Artery Stenosis: Correlations With Fractional Flow Reserve/Intravascular Ultrasound and Prognostic Implications: The iLITRO-EPIC07 Study.
Oriol Rodriguez-Leor José María de la Torre Hernández Tamara García-Camarero Bruno García Del Blanco Ramón López-Palop Armando Pérez de Prado
Circ Cardiovasc Interv
November 2022
Article Synopsis
- This study investigates the agreement between fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) in patients with intermediate stenosis in the left main coronary artery (LMCA), finding an 80% concordance between the two methods.
- The research involved 300 patients and emphasized the role of intravascular ultrasound (IVUS) for assessing cases where FFR and iFR results disagreed, identifying minimal lumen areas as a factor in decision-making.
- Over a 20-month follow-up, deferral of revascularization based on iFR and IVUS showed a lower incidence of major adverse cardiac events compared to those who underwent revascularization, suggesting that deferring treatment
Article Synopsis
- A study evaluated the long-term effects (5 years) of complete bioresorbable vascular scaffold (BVS) resorption on both structural healing and blood vessel function in patients who received the ABSORB-BVS treatment.* -
- The research included 31 patients, showing that while the scaffolds completely dissolved, there were concerning vasomotor responses, such as vasoconstriction after acetylcholine and lack of response to nitroglycerine in the treated blood vessels.* -
- New coronary lesions developed in some patients, indicating potential complications, and while the scaffolds were gone, the expected restoration of healthy blood vessel function was not fully achieved.*
Article Synopsis
- The study investigates how sex and previous cardiovascular disease (CVD) influence 30-day mortality in patients who experienced ST-elevation myocardial infarction (STEMI).
- It analyzed 4,366 patients across 83 centers in Spain, finding that women and those with prior CVD generally had higher unadjusted mortality rates.
- Surprisingly, after adjusting for other factors, the difference in mortality risk between men and women varied; women with prior CVD showed lower mortality risk compared to men, while no difference was evident in patients without CVD.
Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents: EPIC05-Sierra75 study.
Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Armando Perez de Prado
J Geriatr Cardiol
May 2022
Article Synopsis
- The study aimed to evaluate the outcomes of elderly patients (over 75 years) undergoing percutaneous transluminal coronary intervention (PCI) using an antithrombotic strategy that considers their individual risks for bleeding and ischemic events.
- The research included 1,064 patients and found that the incidence of major adverse cardiovascular events and bleeding was lower in this tailored treatment group compared to a control group, with no cases of stent thrombosis in those receiving shorter dual antiplatelet therapy.
- The conclusion indicates that a risk-adjusted antithrombotic protocol for elderly patients after revascularization with the latest stent technology may lead to better health outcomes regarding both bleeding and ischemic events.
Interregional variability in the use of cardiovascular technologies (2011-2019). Correlation with economic indicators, admissions, and in-hospital mortality.
José M de la Torre Hernández Manuel Lozano González Tamara García Camarero David Serrano Lozano Belén Cid Armando Pérez de Prado
Rev Esp Cardiol (Engl Ed)
October 2022
Article Synopsis
- The study examines access to advanced cardiovascular treatments across different regions in Spain, highlighting the need for equal opportunities in a publicly-funded health system.
- Data from the Spanish Society of Cardiology were analyzed from 2011 to 2019, revealing significant disparities in the use of certain procedures like primary PCI and TAVR, with no clear link to economic factors.
- Although some minor correlations with hospital attendance rates emerged, overall, the study indicates variability in technology use without a strong association to regional wealth or in-hospital mortality rates.