Reactivity of the antitumor complex (H2trz)[trans-RuCl4(N2-Htrz)2] in the presence of DNA purines within a fluorinated silica matrix.

The stability of the antitumor Ru(III) complex (H(2)trz)[trans-RuCl(4)(N(2)-Htrz)(2)] within a tailored sol-gel silica matrix was studied, combining the information from UV-vis and infrared spectroscopies. The matrix was synthesized by a one-step sol-gel process catalyzed by hydrofluoric acid, resulting extremely light, hydrophobic and fluorinated. It is shown that upon encapsulation, the complex undergoes a series of processes, starting with the increase in charge density on the metal center, followed by hydrolysis reactions.