Phase characterization of indomethacin in binary solid dispersions with PVP VA64 or Myrj 52.

In the present study the properties of binary solid dispersions made up of PVP VA64, Myrj 52 and indomethacin (IMC) are studied and characterized. The solid dispersions were prepared by dissolving the materials in dichloromethane, followed by solvent evaporation under reduced pressure at 55 degrees C in a rotavapor. Binary solid dispersions were characterized by standard and modulated temperature differential scanning calorimetry (MTDSC), thermogravimetry (TGA) and X-ray powder diffraction (XRPD).

Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole.

The purpose of the present study was to characterize the solid state properties of ternary solid dispersions made up of PVP VA64, Myrj 52 and itraconazole. The solid dispersions were prepared by dissolving the materials in methylene chloride, followed by evaporation under reduced pressure of the solvent at 55 degrees C in a rotovapor. Binary and ternary solid dispersions were characterized by standard and modulated temperature differential scanning calorimetry and X-ray powder diffraction.

Mucosal response in African catfish after administration of Vibrio anguillarum O2 antigens via different routes.

The aim of this study was to investigate the possibility of mucosal vaccination in African catfish (Clarias gariepinus) with Vibrio anguillarum O2 bacterins. The antigen was administered via different routes: anal intubation, oral administration, intraperitoneal injection and immersion. To monitor the antigen uptake, a competitive ELISA was used.

Oral vaccination of African catfish with Vibrio anguillarum O2: effect on antigen uptake and immune response by absorption enhancers in lag time coated pellets.

The impact on antigen uptake and antibody response by the addition of absorption enhancers to Vibrio anguillarum O2 antigen was studied in oral vaccination trials of African catfish (Clarias gariepinus). Oral vaccination was achieved by feeding lag time coated pellets. The lag time coat prevents premature release of the encapsulated vaccine in the tank, before ingestion of the pellets by the fish.

Study of the phase behavior of polyethylene glycol 6000-itraconazole solid dispersions using DSC.

The aim of the present study was to investigate the phase behavior of solid dispersions made up of PEG 6000 and itraconazole using DSC. Solid dispersions were prepared by solvent evaporation. DSC analysis of pure PEG 6000 showed three endothermic events, representing the melting transitions of the three different crystal modifications.

Development of a lag time coating for drug-layered fish feed pellets.

The purpose of this work was to develop a release-delaying coat for drug-layered fish pellets, in order to prevent a premature release of the drug in the tank water but allowing a rapid release after uptake by the fish. Blank pellets were prepared in a rotary processor and drug layered in a Wurster coater with bovine serum albumin or riboflavin using hydroxypropyl methyl cellulose (HPMC) as a binder. On the drug-loaded pellets, different mixtures of ethyl cellulose (EC) and HPMC were applied as the release-delaying coat.

Comparative evaluation of co-processed lactose and microcrystalline cellulose with their physical mixtures in the formulation of folic acid tablets.

In this study, a new co-processed filler-binder ingredient for direct compression, MicroceLac 100, was compared with three different lactoses mixed with microcrystalline cellulose. The aim was to improve a folic acid tablet formulation. Therefore, the influence of drug addition to these mixtures was studied with regard to flow and binding properties.