Publications by authors named "Arlindo Vicente de Assuncao Carvalho"
Dynamic changes in genetic diversity, drug resistance mutations, and treatment outcomes of falciparum malaria from the low-transmission to the pre-elimination phase on the islands of São Tomé and Príncipe.
Malar J
December 2021
Article Synopsis
- Significant progress has been made in reducing malaria cases in São Tomé and Príncipe (STP) through vector control and case management, leading to this study assessing genetic diversity and treatment outcomes of malaria infections from 2010 to 2016.
- Researchers sequenced specific genes related to the malaria parasite and drug resistance in 118 blood samples and analyzed treatment outcomes for 7482 cases, utilizing regression models to identify factors affecting parasite density and treatment failures.
- The study found notable genetic changes in malaria strains within STP, including shifts in predominant alleles and a threefold decrease in average parasite density, while highlighting that younger patients and those treated with quinine were more likely to experience treatment failures.
is an obligate intracellular bacterium that causes scrub typhus in humans. Formerly thought to be confined to the "tsutsugamushi triangle" within the Asia-Pacific region, scrub typhus was recently identified in the Western Hemisphere. Moreover, a new species of bacterial genus was isolated from a patient in Dubai.
View Article and Find Full Text PDFSpotted fever group rickettsiae (SFGR) and Coxiella burnetii are intracellular bacteria that cause potentially life-threatening tick-borne rickettsioses and Q fever respectively. Sao Tome and Principe (STP), small islands located in the Gulf of Guinea, recently experienced a dramatic reduction in the incidence of malaria owing to international collaborative efforts. However, unexplained febrile illnesses persist.
View Article and Find Full Text PDFDengue fever has become a worldwide public health concern, threatening an estimated 40% of the world's population. However, most resources and attention are still focused on malaria, while dengue statuses are poorly recognized in many African countries. In this serological survey, dengue virus (DENV) transmission was demonstrated by using serum samples collected from 78 pregnant women in the Democratic Republic of Sao Tome and Principe (DRSTP) during 2003 to 2004.
View Article and Find Full Text PDF