[Acute experimental bone marrow necrosis in the rabbit induced by aortic ligation. Ultrastructural and biochemical study].

The authors study the effects of ligation of the infra-renal aorta on the bone marrow in the femoral shafts in ten rabbits, from a histopathological and biochemical standpoint. Histology revealed marrow necrosis in nine cases out of ten. They describe the appearances of this necrosis by light and electron microscopy.

[A massive bone metastasis of prostatic origin (author's transl)].

The authors report the case of a 68 year old man with histologically proven cancer of the prostate who progressively developed an ischioperineal tumor interfering with sitting, and in the pelvis x-ray it was ovular measuring 16 X 7.5 cm. This bone tumor, developed at the expense of the right ischeopublic ramus and the ischeal tuberosity, was well limited and circumscribed, with its central portion dense and the periphery giving a septate appearance.

[Biological and histological profile of osteomalacia in condensing prostatic osteosis. Apropos of 4 cases].

The authors report on 4 cases of condensating prostatic osteosis, whose biological picture and histomorphometric lesions in the involved area indicate osteomalacia. They discuss the individual nature of such a syndrome, the links between vitamin D deficiency and hyperosteoidosis at a very slow noted speed of calcification, and the usefulness of investigating and treating the syndrome.

[Histopathology of bone and cartilage lesions in reflex sympathetic dystrophy of the knee. Apropos of 16 cases].

In 16 cases of reflex sympathetic dystrophy of the knee, the authors obtained by drill biopsy 29 bone samples from the epiphyseal and metaphyseal regions of the femur and tibia and 8 cartilagenous samples (including 6 by arthrotomy and 2 after patellectomy). They noted thinning of the cortical bone, lacunae of cortical reabsorption, rarefaction of the trabeculae, of which some were dead, stasis and fibrosis of the bone marrow. The 8 cartilage samples were pathological, with, in particular, fibrosis of the surface cartilage (vascular pannus formation).

[Pubic and ischio-pubic osteitis. Bacteriological and histopathological study of the pubic bone].

The authors present 11 cases of pubic or ischio-pubic osteitis of which ten had undergone bone biopsy by aspiration, needle biopsy, or surgery. In 7 cases, a germ was isolated by culture of the bone sample. In 2 cases, there were purulent and necrotic lesions on pathological examination of the fragment.

[Pathologic anatomy of infectious osteoarthritis].

Infection of the joint with pyogenic organisms usually causes purulent arthritis the prognosis of which is linked to the severity of the bone, cartilage and ligamentous destruction. The tissue response to infection is moreover influenced by a certain number of factors such as the nature of the bacteria and, above all, the circumstances of onset of the infections. Considering the difficulties in diagnosis, special mention should be made of bone and joint infections with a torpid course.

[Chondromalacia of the hip].

The authors have shown that the initial phase of coxarthrosis consists purely of cartilaginous lesions, not visible in radiographs. They have studied 200 arthrograms of the hip using a precise technique which is described. They have found cartilaginous lesions both in cases of insufficiency of the lateral wall of the acetabulum, and in cases of insufficiency of the medial wall of the acetabulum.

Regional femur blood flow measurements with radiolabelled microspheres in fatty liver-induced or corticosteroid treated animals: preliminary report.

Using radio-labelled microspheres, the authors studied bone blood flows in various segments of goose femurs (femoral head, trochanter, condyles). Experiments were conducted on three groups of geese: control, fatty liver induced and corticosteroid-treated animals. The preliminary results suggest that hyperlipemia and fatty liver conditions do not seem to obviously disturb intra osseous blood circulation in fatty geese, although corticosteroids might affect bone blood flows in condyles.

[Crystal chemistry of two cases of subdeltoid calcification].

We studied the mineral phase of two cases of subdeltoid calcification by thermogravimetry, infrared spectometry and X ray diffraction. We have shown that these were phosphates deficient in calcium ions with an apatite structure. They contained both carbonate ions and HPO4 ions in variable proportions from one sample to another.

[D-penicillamine in rheumatoid arthritis : hematological incidents and accidents (author's transl)].

From literature data and their own experience, the authors comment hematological complications, related to the use of D-penicillamine, mainly in theumatoïd arthritis. Hypereosinophilia is more common than thrombopenia, but, both complications are usually benign. Anemia alone is very rare.

[Local osseous blood flow measured with radioactive microspheres: correlations with intra-medullary pressures].

The authors studied in the dog, using radioactive microspheres, the blood bone outputs of the trochanter, the femoral diaphysis and the tibial diaphysis, and measured, in a simultaneous fashion, the intra-medullar pressures in these bone regions. A same hierarchy of outputs is consistently found in all animals : the trochentarian outputs are always the highest, and next come, in decreasing order, the outputs of the femoral diaphyses and the tibias. On the other hand, the intra-medullar pressures, although differing according to the bone regions, always have rather superposable rates, so that the neighboring intra-medullar pressures always correspond to radically different outputs.

[Acute leukaemias after treatment using cytotoxic agents for rheumatological purpose. 19 cases among 2006 patients(author's transl)].

The authors undertook a retrospective study to determine the number of acute leukaemias developing amongst 2006 patients suffering from chronic inflammatory rheumatic conditions and connective tissue disorders, treated with cytotoxic agents. The follow-up period ranged from 1 to 13 years. Nineteen leukaemias were found, essentially granulocytic, with a latent period of 5.

[Histopathology of bone lesions in 9 cases of algodystrophy of the hip].

The authors present the results of histo-pathological observations made in 9 cases of sympatic algodystrophy reflex of the hip, subjected to a punch biopsy of the head and neck of the femur. The punch biopsy was decided upon, either because of difficult diagnosis, or because of the abnormally long duration of the pain syndrome. In all cases, there were bone lesions.

[Coxarthroses due to ischemia. Ischemic coxarthropathy].

In the first part of their work, the authors present radiological, histopathological and experimental results showing that cartilage of the joint can be originally damaged by articular ischemia. In the second part, they analyze the clinical and radiological features of 40 cases of ischemic coxarthrosis, substantiated by histological examination: these are chronic coxarthropathies with changes in the cartilage without rupture of the femoral head but with medullary necrosis and often trabecular necrosis involving the head and the neck of the femur. These ischemic coxarthroses are most often well centered with a superior or supero-internal pinching and show few osteophytes.

[Marrow scintigraphy in Paget's disease of bone (author's transl)].

Marrow scintigraphy using 99mTc colloids was performed in 20 patients with Paget's disease of bone and compared with skeletal scanning in each of them. As long as the regions explored were haematopoietically active, despite the advanced age of the patients, there was decreased marrow uptake in regions of increased uptake on the skeletal scan. Whilst increased uptake of pyrophosphate reflects bone hyperosteogenesis, decreased uptake of colloids reflects marrow fibrosis, and early histological sign of the disease.