Publications by authors named "Arlene J Gonzalez"
Am J Hum Genet
December 2015
Article Synopsis
- Genome-wide association studies (GWAS) have linked over 150 genetic loci to blood lipid and cholesterol levels, but many underlying mechanisms are still unclear.
- Research focused on the GALNT2 locus revealed 25 noncoding variants associated with total cholesterol, with specific variants like rs2281721 showing significant differences in regulatory enhancer activity.
- Further experiments confirmed that certain alleles increased GALNT2 gene expression, indicating that both rs4846913 and rs2281721 may significantly influence cholesterol levels by modulating GALNT2 function.
