Objective: To report three cases of bilateral Acanthamoeba keratitis in association with Synergeyes hybrid contact lens wear.
Methods: Retrospective case series of six eyes of three patients that developed Acanthamoeba keratitis with Synergeyes hybrid contact lens wear.
Results: Acanthamoeba keratitis was diagnosed in six eyes with a previous misdiagnosis of Herpes simplex keratitis in two patients and a misdiagnosis of corneal graft rejection in the third patient.