[The role of delta-sleep-inducing peptide in the normalization of cardiac electric stability in experimental emotional stress].

In chronic experiments on rabbits, a delta-sleeping inducing peptide was tested for effects on the cardiac electric stability and onset of ventricular premature beats during experimental emotional stress. The peptide in a dose of 60 nm/kg was found to normalize the thresholds of ventricular fibrillation and its predictors and to decrease or abolish spontaneous ventricular premature beats occurring during the stress. This suggests that the delta-sleep-inducing peptide may be used to prevent cardiac arrhythmias during stresses.

[Effect of delta-sleep inducing peptide on electrical instability of the heart in emotional stress].

The effect of the delta-sleep inducing peptide (DSIP) on disorders of the cardiac rhythm in emotional stress was studied in experiments on rabbits. DSIP (60 nmol/kg) diminished or arrested ventricular extrasystole occurring in experimental emotional stress. It was shown that the antiarrhythmic effect of DSIP is most manifest if it is injected just before exposure to the stress factors.

[Neuroendocrine mechanisms of participation of the raphe nuclei in the development of hypertensive reactions in emotional stress].

The experiments on cats and rabbits have studied electroencephalographic, endocrine and blood pressure responses to stress (5-hour immobilization with electrical foot shock) before and after coagulation of the midbrain nuclei raphe. Blood pressure and adrenal responses in advanced (4-hour) stress were elevated in intact animals, the responses attenuating after coagulation of the nuclei raphe. Background bioelectrical activity of the midbrain reticular formation and hypothalamus was found to be activated in the operated animals.

[Neurophysiological analysis of the development of endocrine and hypertensive reactions in long-term emotional stress].

A study was made of the effect of chronic emotional stress on the formation of hypertension in animals. This was shown to be related to dynamic changes in the function of the CNS, particularly in the hypothalamic apparatus of the neuroendocrine control. The above changes played a role in the formation of hypertensive vascular reactions accompanied by a high hormonal secretion of the adrenal cortex and thyroid.

[Correlations of central nervous system and thyroid function under chronic emotional stress].

Experiments on cats exposed to chronic emotional stress induced during one week by 4-hour immobilization of the animals in conjunction with aperiodic electrocutaneous stimulation were made to study correlations of the time course of changes in the EEG of the cortical and subcortical structures and the content of thyroxin in the peripheral blood at varying time of the experiments. It was demonstrated that in the course of stress, the EEG manifests the cycles of "burst" activity of slow waves, which are first recorded in the posterior hypothalamus and then get generalized. This is accompanied by a significantly high thyroxin secretion.

[Mechanism of the effect of the midbrain reticular formation on the hypothalamus-hypophysis-thyroid gland system].

The role of the posterior hypothalamic nuclei in the transmission of the influences of the mesencephalic reticular formation upon the thyroid hormone secretion was studied. Stimulation of the mesencephalic reticular formation in anesthetized cats was followed by the excitation of the thyroid hormoone secretion: the content of the blood protein-bound iodine was increased. This effect was eliminated after the bilateral coagulation of the posterior hypothalamic nuclei.