Proteomic changes during experimental de- and remyelination in the corpus callosum.

Background: In the cuprizone model of multiple sclerosis, de- and remyelination can be studied without major interference from the adaptive immune responses. Since previous proteomic studies did not focus on the corpus callosum, where cuprizone causes the most pronounced demyelination, we performed a bottom up proteomic analysis on this brain region.

Methods: Eight week-old mice treated with 0.