The clinical features, histological subtypes and management of dermatofibrosarcoma protuberans (DFSP) are reviewed in this article. DFSP is an uncommon cutaneous sarcoma first described in 1890. It has a high local recurrence rate, low metastatic rate and low mortality.
View Article and Find Full Text PDFBackground: Melanoma in-transit metastases (ITMs) are a challenge to treat and associated with systemic disease and poor prognosis. Topical diphencyprone (DPCP), a potent contact sensitizer, is an established treatment for melanoma ITMs. This exploratory study investigated the utility of BRAF mutation status, CD8, PD-1, PD-L1, and TILs distribution as biomarkers for response of ITMs to topical immunotherapy (DPCP).
View Article and Find Full Text PDFDermatol Online J
November 2009
Cystic sebaceous neoplasms are uncommon and almost always regarded as a consistent marker for Muir-Torre syndrome. We present a 73-year-old man with a cystic sebaceous neoplasm on his arm, clinically not associated with Muir-Torre syndrome.
View Article and Find Full Text PDFInt J Surg Pathol
August 2011
Glomus tumors are neoplasms differentiating toward specialized cells found in the glomus body, a structure involved in thermoregulation. Although the vast majority is benign, the occurrence of malignant glomus tumors is well recognized. Criteria for prediction of malignant potential include a deep location, large size, infiltration, necrosis, and nuclear atypia.
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