Publications by authors named "Arjun Maniyedath"
Article Synopsis
- bRT before CAR T-cell therapy for LBCL is gaining traction, but its impact on treatment outcomes is unclear.
- A study analyzed 23 LBCL patients who underwent bRT followed by CAR T-cell therapy, focusing on various PET scan metrics to measure tumor response.
- Results revealed that significant decreases in SUV and MTV during bRT were linked to better progression-free survival, freedom from distant progression, and local control.
- The findings suggest that greater cytoreduction via bRT may enhance the effectiveness of subsequent CAR T-cell therapy in treating large B-cell lymphoma.
Purpose: Positron emission tomography (PET)-guided radiation therapy is a novel tracked dose delivery modality that uses real-time PET to guide radiation therapy beamlets. The BIOGUIDE-X study was performed with sequential cohorts of participants to (1) identify the fluorodeoxyglucose (FDG) dose for PET-guided therapy and (2) confirm that the emulated dose distribution was consistent with a physician-approved radiation therapy plan.
Methods And Materials: This prospective study included participants with at least 1 FDG-avid targetable primary or metastatic tumor (2-5 cm) in the lung or bone.