The relationship between cytokine gene polymorphism and unexplained recurrent spontaneous abortion in Saudi females.

Objective: To investigate the relationships between unexplained recurrent spontaneous abortion (RSA) and single nucleotide polymorphisms tumor necrosis factor-alpha (TNF-alpha) (-238 G/A, -308 G/A), interleukin (IL)-6 (-634 G/C) and IL-10 (-592 C/A) in the promoter region of 3 different interleukin (TNF-alpha, IL-6, and IL-10) genes.

Methods: The study group comprised 65 women (mean age: 34.1+/-6.