Publications by authors named "Ariya Shiwram"
Article Synopsis
- Ovarian and endometrial cancers with -amplification often resist standard treatments, indicating a significant clinical challenge.
- A study identified that the PKMYT1 inhibitor, lunresertib, combined with the ATR inhibitor, camonsertib, can effectively target -amplification-related replication stress, leading to increased cancer cell death.
- This combination therapy demonstrated durable antitumor effects and improved survival in xenografts from patients and cell lines, suggesting a new treatment strategy focused on enhancing CDK1 activity for these cancer types.
