A Completely Metal-Free Protocol for Oxidative Desulfitative C-N Coupling Reaction in Non-Basic Condition.

A metal free oxidative desulfitative C-N coupling reaction through activation of latent thiol group using hypervalent iodine reagent is being reported in eco-friendly solvent ethanol. Here, the thio-amide group present in 5-alkylidene-rhodanine has been utilized as latent thiol functionality and C-N coupling with amines is realized. The reaction occurs evading the use of metal catalysts, inert atmosphere, high temperature or microwave heating, and strong base which is normally required for metal catalyzed C-N coupling reaction.