Investigating the Comparative Effects of Six Artemisinin-based Combination Therapies on -induced Hepatorenal Toxicity.

Background: Too many artemisinin-based combination therapies (ACTs) are available, thus creating a dilemma on the most preferred for the treatment of malaria.

Aim: We compared the effect of six ACTs in mitigating -induced hepatorenal toxicity in experimental malaria.

Materials And Methods: Forty adult male Swiss mice allotted into eight groups: Group 1 (normal control [NC] uninfected and untreated), Group 2 (parasitized nontreated - [PNT]), and Groups 3-8 received inoculum.

Evaluation of in vivo antimalarial activities of ethanolic leaf and seed extracts of Telfairia occidentalis.

The leaves and seeds of Telfairia occidentalis are used as vegetables in making soups in Southern Nigeria. In this study, we investigated the antimalarial activity of leaf and seed extracts in vivo in mice infected with Plasmodium berghei berghei during early and established infections. T.