Investigating the Comparative Effects of Six Artemisinin-based Combination Therapies on -induced Hepatorenal Toxicity.

Background: Too many artemisinin-based combination therapies (ACTs) are available, thus creating a dilemma on the most preferred for the treatment of malaria.

Aim: We compared the effect of six ACTs in mitigating -induced hepatorenal toxicity in experimental malaria.

Materials And Methods: Forty adult male Swiss mice allotted into eight groups: Group 1 (normal control [NC] uninfected and untreated), Group 2 (parasitized nontreated - [PNT]), and Groups 3-8 received inoculum.

Evaluation of in vivo antimalarial activities of ethanolic leaf and seed extracts of Telfairia occidentalis.

The leaves and seeds of Telfairia occidentalis are used as vegetables in making soups in Southern Nigeria. In this study, we investigated the antimalarial activity of leaf and seed extracts in vivo in mice infected with Plasmodium berghei berghei during early and established infections. T.

Effects of the fruit of Telfairia occidentalis on some biomolecules in rat.

The effects of the ethanolic fruit extract of T. occidentalis on some enzymes and biochemical parameters were evaluated in rats. 100, 500 and 1000 mg kg(-1) of the extract were administered orally and once daily to three different groups of rats, respectively, for 28 days.

Hypoglycemic effect of the seed extract of Telfairia occidentalis in rat.

The blood glucose lowering effect of the ethanolic extract of the seed of Telfaria occidentalis in normoglycemic, alloxan-diabetic and glucose loaded rats was determined. Ethanolic extract of the seed of Telfairia occidentialis was administered at two dose levels (100 and 250 mg kg(-1)) to both normoglycemic and alloxan diabetic Wilstar albino rats. Blood was collected from the tail vein of the rats at 1, 2 and 4 h.