[A differentiated approach to Parkinson's disease treatment in early stage of the disease].

A conception of the approach to Parkinson's disease treatment at early stage, which could be realized in practice is suggested. The conception is based on the results of dopaminergic drugs treatment of 149 patients, aged 33-87 years. The patient's state was assessed by neurological examination and clinical scales with regard to different disease types, tremor and rigid, and levodopa doses--from moderate (up to 500 mg) to high (above 500 mg).

[Clinical features of an early stage of Parkinson's disease].

One hundred and forty-nine patients with Parkinson's disease (PD), mean age 66.3 years, have been examined. It was found that the early stage of the disease might include isolated depression, minimal movement disorders and functional compensation, the latter being observed during L-Dopa treatment.

[Control and assessment of the quality of professional competence among physicians and students].

The paper presents a new test method of control which permits to estimate objectively both formal knowledges of students, hospital physicians, post-graduates, physicians and their ability for logical reasoning, for determination of cause-effect relationships between separate phenomena. The list of the standards generally accepted for the test's tasks is proposed as well as recommendations for the users are given. 6 variations of the test's tasks are presented as the examples.

[Experience in using T-activin in multiple sclerosis patients].

Forty patients with multiple sclerosis of a differing course, duration and severity were treated in this series. T-activin was employed as an immunocorrective agent (AFT-6 fraction). The immunological status was assessed in all patients observed prior to, during and after the treatment.

[Clinico-electrophysiologic, immunologic and biochemical studies of multiple sclerosis patients].

Immunological blood indices, neutral lipid fractions, level of daily urine C21-corticosteroid excretion, free amino acid spectrum of the blood were studied in 72 patients with disseminated sclerosis. The EEG, EMG and REG data were analyzed. Healthy persons of the same age formed the control group.

[Various pathogenetic mechanisms of ischemic stroke in cardiac rhythm disorders].

Computerized results of polygraphic examinations of EEGs, ECGs, sphygmograms of the temporal artery, and phlebograms of the jugular vein carried out in 60 patients with a history of ischemic stroke and attendant heart rhythm disorders are discussed. The control group comprised 30 practically healthy subjects. The studies showed that in cases of ischemic stroke, there is a direct relationship between the degree of changes in the cerebral bioelectric activity and the intensity of disorders in general hemodynamics, which may be accounted for by the disruption of the vascular tone autoregulation, largely on the side of the ischemic focus.

[Cerebral syndrome in chronic nonspecific lung diseases].

An analysis of the results of clinico-electrophysiological examinations of 89 patients suffering from chronic nonspecific inflammatory diseases of the lungs with involvement of the nervous system is presented. The clinical syndromes of the nervous system affections in patients with chronic inflammatory pulmonary diseases are specified. Of importance in the pathogenesis of these affections are progressing hypoxia, intoxication, edema of the brain and the meninges, and the effects of the infectious factors on the vascular walls and the nervous cells.

[Hyperkinesis in acute renal failure (clinico-pathomorphologic studies)].

Results of clinical and pathomorphological examinations of 74 patients with acute renal insufficiency are presented. Various forms of hyperkineses accompanying the grave course of acute renal insufficiency complicated with comatose state are described. The development of hyperkineses in patients with acute renal insufficiency is prognostically unfavourable.

[Changes in the nervous system in patients with paroxysmal tachycardia].

The authors studied changes in the nervous system of 85 patients with paroxysmal tachycardia. Clinico-electrophysiological correlations permitted to detect the diverse symptoms of the nervous system lesions. The examinations established correlations between the focal neurological symptoms, the zone of ischemia in the basin of certain arteris and the EEG and REG data.

[Cerebral syndromes in acute pneumonias].

The paper deals with an analysis of some clinical and electrophysiological (EEG, EMG, REG) studies in 300 patients with focal and croupous pneumonia accompanied by the nervous system lesions. The authors distinguish clinical syndromes of the nervous system lesions in acute pneumonia. It was possible to demonstrate a certain correlation between the character of electrophysiological data and the severity, localization of pneumonia, and the prevalent lesions in different parts of the nervous system.

[Semiologic, biochemical and electrophysiologic analysis of the stages of apopleptic coma].

The paper contains some results of a comprehensive clinical, biochemical and electrophysiological study of 120 patients with different stages of an apoplectic coma. The authors studied the gas content, acid-base balance of the cranial blood inflow and outflow in the CSF and changes of EEG and EMG. It was shown that there were different levels of CNS lesions (cortico-subcortical, meso-diencephalic, meso-pontile and bulbar level) which corresponded to certain correlations between clinical, biochemical, EEG and EMG findings.