Safety of high-intensity corneal collagen crosslinking.

Purpose: To evaluate the safety of a new high-intensity corneal collagen crosslinking (CXL) treatment protocol for keratoconus.

Setting: Vardinoyiannion Eye Institute of Crete, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.

Design: Prospective interventional case series.

Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation.

Purpose: To compare the visual and refractive outcomes and the corneal structural changes in myopic patients after surface refractive treatments (ie, photorefractive keratectomy [PRK] with adjuvant mitomycin-C [MMC] and epithelial laser in situ keratomileusis [epi-LASIK]).

Setting: University of Crete, Heraklion, Crete, Greece.

Design: Prospective comparative case series.

Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients.

Purpose: To evaluate and compare the depth of the corneal stromal demarcation line after corneal collagen cross-linking (CXL) using 2 different methods: confocal microscopy and anterior segment optical coherence tomography (AS OCT).

Design: Prospective, comparative, interventional case series.

Methods: Seventeen patients (18 eyes) with progressive keratoconus were enrolled.

Effect of corneal collagen cross-linking on corneal innervation, corneal sensitivity, and tear function of patients with keratoconus.

Purpose: To evaluate the effect of corneal collagen cross-linking (CXL) on corneal innervation, corneal sensitivity, and tear function in patients with keratoconus.

Design: Prospective, interventional case series.

Participants: Twenty-four patients with bilateral keratoconus (30 eyes) who presented to the Institute of Vision and Optics, University of Crete, from May 2008 to October 2008.

Prospective study of foveal thickness alterations after cataract surgery assessed by optical coherence tomography.

Background/aims: To evaluate the alterations of mean foveal thickness (MFT) and visual acuity (VA) outcomes after uncomplicated cataract surgery in different groups of patients.

Methods: This study included eyes of consecutive patients who underwent cataract surgery between November 2007 and June 2009. The patients included in the study were divided into 4 groups, as follows: history-free patients, patients with diabetes mellitus without macular involvement at baseline, patients with glaucoma, and patients with epiretinal membrane (ERM).

Detection of macular function changes in early (AREDS 2) and intermediate (AREDS 3) age-related macular degeneration.

Background/aim: To evaluate if retinal sensitivity values obtained with a dedicated (screening) device can be used to functionally identify early and intermediate age-related macular degeneration (ARMD).

Methods: A fully automatic fundus perimeter combined with an image-stabilized scanning laser ophthalmoscope was used in 200 ARMD patients (319 eyes) in 5 study sites. The age-matched control group consisted of 200 normals.

Evaluation of image quality metrics for the prediction of subjective best focus.

Purpose: Seven existing and three new image quality metrics were evaluated in terms of their effectiveness in predicting subjective cycloplegic refraction.

Methods: Monochromatic wavefront aberrations (WA) were measured in 70 eyes using a Shack-Hartmann based device (Complete Ophthalmic Analysis System; Wavefront Sciences). Subjective cycloplegic spherocylindrical correction was obtained using a standard manifest refraction procedure.

Mitomycin C aqueous humor concentration after photorefractive keratectomy: an experimental study.

Purpose: To evaluate mitomycin C (MMC) aqueous humor concentration after photorefractive keratectomy (PRK).

Methods: In this experimental study, twenty-four eyes of 12 male pigmented rabbits were divided into 4 groups and studied at the Institute of Vision and Optics, Department of Medicine, University of Crete, Greece. Eyes in groups 1 and 2 underwent PRK to correct -5 diopters (D) in a 6-mm optical zone, while sponges soaked with 0.

Higher-order aberrations produce orientation-specific notches in the defocused contrast sensitivity function.

Local minima or notches in the defocused contrast sensitivity function (CSF) have been linked to the aberrations of the eye. We use theoretical modeling of the effects of the aberrations to show these notches can be orientation-selective due to the effects of aberration terms such as coma and trefoil. Notches that changed with orientation were observed in the defocused CSF of four subjects.

Confocal scanning laser tomography analysis of choroidal neovascularization and correlation with quantitative fluorescein angiography.

Purpose: To investigate the agreement between confocal scanning laser tomography and quantitative fluorescein angiography in the analysis of retinal-thickness changes in patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).

Materials And Methods: The edema index of a cSLT was measured in 18 eyes of 16 patients with CNV secondary to AMD that underwent photodynamic therapy (PDT) with Visudyne. Measurements were taken 1 hour before as well as 1 hour, 1 month, and 3 months after therapy.

One-year follow-up of corneal confocal microscopy after corneal cross-linking in patients with post laser in situ keratosmileusis ectasia and keratoconus.

Purpose: To investigate corneal tissue alterations after corneal collagen cross-linking in patients with post laser in situ keratosmileusis (LASIK) keratectasia and keratoconus.

Design: Prospective comparative case series.

Methods: Five patients (5 eyes) with iatrogenic keratectasia after LASIK and 5 patients (5 eyes) with progressive keratoconus were included.

Alterations in endothelial cell density after photorefractive keratectomy with adjuvant mitomycin.

Purpose: To elucidate the distinct role of the intraoperative use of mitomycin C (MMC) on endothelial cell density after photorefractive keratectomy (PRK) in human eyes.

Design: Prospective, double-masked, randomized clinical trial.

Methods: One eye of 15 patients was treated with PRK with intraoperative use of topical 0.

The effect of ocular aberrations on steady-state errors of accommodative response.

It is well accepted that the accommodation system is characterized by steady-state errors in focus. The purpose of this study was to correlate these errors with changes in ocular wavefront aberration and corresponding image quality when accommodating. A wavefront analyzing system, the Complete Ophthalmic Analysis System (COAS), was used in conjunction with a Badal optometer to allow continuous recording of the aberration structure of the eye for a range of accommodative demands (up to 8 D).

Intraobserver repeatability of macula measurements by confocal scanning laser tomography.

Purpose: To assess the repeatability of macula measurements provided by the Heidelberg Retina Tomograph II (HRT II) in normal subjects, patients with diabetic macular edema (DME), and patients with choroidal neovascularization (CNV).

Design: Prospective, observational case.

Setting: Institutional-based study.

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer.

Background: Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting should not be considered a priori precise. We report on the variability of such an instrument at two different pupil sizes.