Joint meta-analysis of two diagnostic tests accounting for within and between studies dependence.

There is an extensive literature on methods for meta-analysis of diagnostic test accuracy, but it mainly focuses on a single test. A multinomial generalised linear mixed model was recently proposed for the joint meta-analysis of studies comparing two tests on the same participants in a paired tests design with a gold standard. In this setting, we propose a novel model for joint meta-analysis of studies comparing two diagnostic tests which assumes independent multinomial distributions for the counts of each combination of test results in diseased and non-diseased patients, conditional on the latent vector of probabilities of each combination of test results in diseased and non-diseased patients.

Factor Tree Copula Models for Item Response Data.

Factor copula models for item response data are more interpretable and fit better than (truncated) vine copula models when dependence can be explained through latent variables, but are not robust to violations of conditional independence. To circumvent these issues, truncated vines and factor copula models for item response data are joined to define a combined model, the so-called factor tree copula model, with individual benefits from each of the two approaches. Rather than adding factors and causing computational problems and difficulties in interpretation and identification, a truncated vine structure is assumed on the residuals conditional on one or two latent variables.

Bi-factor and Second-Order Copula Models for Item Response Data.

Bi-factor and second-order models based on copulas are proposed for item response data, where the items are sampled from identified subdomains of some larger domain such that there is a homogeneous dependence within each domain. Our general models include the Gaussian bi-factor and second-order models as special cases and can lead to more probability in the joint upper or lower tail compared with the Gaussian bi-factor and second-order models. Details on maximum likelihood estimation of parameters for the bi-factor and second-order copula models are given, as well as model selection and goodness-of-fit techniques.

Factor copula models for mixed data.

We develop factor copula models to analyse the dependence among mixed continuous and discrete responses. Factor copula models are canonical vine copulas that involve both observed and latent variables, hence they allow tail, asymmetric and nonlinear dependence. They can be explained as conditional independence models with latent variables that do not necessarily have an additive latent structure.

An extended trivariate vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable outcomes.

A recent paper proposed an extended trivariate generalized linear mixed model (TGLMM) for synthesis of diagnostic test accuracy studies in the presence of non-evaluable index test results. Inspired by the aforementioned model we propose an extended trivariate vine copula mixed model that includes the TGLMM as special case, but can also operate on the original scale of sensitivity, specificity, and disease prevalence. The performance of the proposed vine copula mixed model is examined by extensive simulation studies in comparison with the TGLMM.

A multinomial quadrivariate D-vine copula mixed model for meta-analysis of diagnostic studies in the presence of non-evaluable subjects.

Diagnostic test accuracy studies observe the result of a gold standard procedure that defines the presence or absence of a disease and the result of a diagnostic test. They typically report the number of true positives, false positives, true negatives and false negatives. However, diagnostic test outcomes can also be either non-evaluable positives or non-evaluable negatives.

A D-vine copula mixed model for joint meta-analysis and comparison of diagnostic tests.

For a particular disease, there may be two diagnostic tests developed, where each of the tests is subject to several studies. A quadrivariate generalised linear mixed model (GLMM) has been recently proposed to joint meta-analyse and compare two diagnostic tests. We propose a D-vine copula mixed model for joint meta-analysis and comparison of two diagnostic tests.

Hybrid copula mixed models for combining case-control and cohort studies in meta-analysis of diagnostic tests.

Copula mixed models for trivariate (or bivariate) meta-analysis of diagnostic test accuracy studies accounting (or not) for disease prevalence have been proposed in the biostatistics literature to synthesize information. However, many systematic reviews often include case-control and cohort studies, so one can either focus on the bivariate meta-analysis of the case-control studies or the trivariate meta-analysis of the cohort studies, as only the latter contains information on disease prevalence. In order to remedy this situation of wasting data we propose a hybrid copula mixed model via a combination of the bivariate and trivariate copula mixed model for the data from the case-control studies and cohort studies, respectively.

Correlation structure and variable selection in generalized estimating equations via composite likelihood information criteria.

The method of generalized estimating equations (GEE) is popular in the biostatistics literature for analyzing longitudinal binary and count data. It assumes a generalized linear model for the outcome variable, and a working correlation among repeated measurements. In this paper, we introduce a viable competitor: the weighted scores method for generalized linear model margins.

A vine copula mixed effect model for trivariate meta-analysis of diagnostic test accuracy studies accounting for disease prevalence.

A bivariate copula mixed model has been recently proposed to synthesize diagnostic test accuracy studies and it has been shown that it is superior to the standard generalized linear mixed model in this context. Here, we call trivariate vine copulas to extend the bivariate meta-analysis of diagnostic test accuracy studies by accounting for disease prevalence. Our vine copula mixed model includes the trivariate generalized linear mixed model as a special case and can also operate on the original scale of sensitivity, specificity, and disease prevalence.

A mixed effect model for bivariate meta-analysis of diagnostic test accuracy studies using a copula representation of the random effects distribution.

Diagnostic test accuracy studies typically report the number of true positives, false positives, true negatives and false negatives. There usually exists a negative association between the number of true positives and true negatives, because studies that adopt less stringent criterion for declaring a test positive invoke higher sensitivities and lower specificities. A generalized linear mixed model (GLMM) is currently recommended to synthesize diagnostic test accuracy studies.

Factor copula models for item response data.

Factor or conditional independence models based on copulas are proposed for multivariate discrete data such as item responses. The factor copula models have interpretations of latent maxima/minima (in comparison with latent means) and can lead to more probability in the joint upper or lower tail compared with factor models based on the discretized multivariate normal distribution (or multidimensional normal ogive model). Details on maximum likelihood estimation of parameters for the factor copula model are given, as well as analysis of the behavior of the log-likelihood.

Weighted scores method for regression models with dependent data.

There are copula-based statistical models in the literature for regression with dependent data such as clustered and longitudinal overdispersed counts, for which parameter estimation and inference are straightforward. For situations where the main interest is in the regression and other univariate parameters and not the dependence, we propose a "weighted scores method", which is based on weighting score functions of the univariate margins. The weight matrices are obtained initially fitting a discretized multivariate normal distribution, which admits a wide range of dependence.

Multivariate logit copula model with an application to dental data.

Applications of copulas for multivariate continuous data abound but there are only a few that treat multivariate binary data. In the present paper, we model multivariate binary data based on copulas using mixtures of max-infinitely divisible copulas, introduced by Joe and Hu (J. Multivar.

Short-term effects of ambient particles on cardiovascular and respiratory mortality.

Background: Particulate air pollution is associated with increased mortality. There is a need for European results from multicountry databases concerning cause-specific mortality to obtain more accurate effect estimates.

Methods: We report the estimated effects of ambient particle concentrations (black smoke and particulate matter less than 10 mum [PM10]) on cardiovascular and respiratory mortality, from 29 European cities, within the Air Pollution and Health: a European Approach (APHEA2) project.