Publications by authors named "Aristid Ekollo Mbange"
High HIV-1 Virological Failure and Drug Resistance among Adult Patients Receiving First-Line ART for At least 12 Months at a Decentralized Urban HIV Clinic Setting in Senegal before the Test-and-Treat.
Aristid Ekollo Mbange Abou Abdallah Malick Diouara Halimatou Diop-Ndiaye Ndèye Aminata Diaw Diouf Ndèye Fatou Ngom-Ngueye
Infect Dis (Auckl)
May 2021
Article Synopsis
- The study investigated HIV-1 virological failure (VF) and drug resistance (DR) in two urban clinic settings in Senegal, focusing on challenges faced in decentralized ART monitoring in sub-Saharan Africa.
- Out of 278 HIV-1-infected adults on first-line ART, 11.5% experienced VF, with significant drug resistance mutations found in 74.1% of the genotyped viral isolates.
- Key predictors of VF and DR included the decentralized clinic site, low CD4 counts (<350 cells/mm), and the use of nevirapine-based therapies, with a notably higher VF rate observed at the Saint-Louis clinic compared to the Dakar clinic.
Objectives: Disruption in HIV care provision may enhance the development and spread of drug resistance due to inadequate antiretroviral therapy. This study thus determined the prevalence of HIV-1 transmitted drug resistance (TDR) in settings of decentralized therapy and care in Senegal and, the Ebola outbreak in Guinea. Antiretroviral-naïve patients were enrolled following a modified WHO TDR Threshold Survey method, implemented in Senegal (January-March 2015) and Guinea (August-September 2015).
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