Application of next generation sequencing in cardiology: current and future precision medicine implications.

Inherited cardiovascular diseases are highly heterogeneous conditions with multiple genetic loci involved. The application of advanced molecular tools, such as Next Generation Sequencing, has facilitated the genetic analysis of these disorders. Accurate analysis and variant identification are required to maximize the quality of the sequencing data.

Markedly elevated troponin and NT-proBNP and myocardial dysfunction in an adolescent with severe diabetic ketoacidosis: A case report.

Severe diabetic ketoacidosis (DKA), rarely, may be associated with elevated troponin and proBNP levels in adults with a history of diabetes. However, few cases have reported this association in children with severe and complicated DKA. We describe a case of severe DKA (pH: 6.

Incentives and limitations of Greek blood donors: Application of the Health Belief Model in the design of recruiting strategies.

Background: Studies of the behavior of blood donors suggest that the examination of their incentives and reported barriers could be utilized in designing targeted recruiting strategies and awareness-raising campaigns.

Methodology: Data was collected via a questionnaire based on the Health Belief Model (HBM), aimed to examine reported incentives, limitations, benefits, and self-efficacy of 261 blood donors at Thriasio General Hospital from January 1 to March 1, 2020, after required permission provided. The analysis was performed by the use of the SPSS statistical software.

Recent Advances in Ruthenium-Catalyzed Hydrogenation Reactions of Renewable Biomass-Derived Levulinic Acid in Aqueous Media.

Levulinic acid (LA) is classified as a key platform chemical for the development of future biorefineries, owing to its broad spectrum of potential applications and because it is simply available from lignocellulosic biomass through inexpensive and high-yield production routes. Catalytic hydrogenation reactions of LA into the pivotal intermediate compound γ-valerolactone (GVL), and beyond GVL to yield valeric acid (VA), 1,4-pentanediol (1,4-PDO), and 2-methyltetrahydrofuran (2-MTHF) have gained considerable attention in the last decade. Among the various transition metals used as catalysts in LA hydrogenation reactions, ruthenium-based catalytic systems have been the most extensively applied by far, due to the inherent ability of ruthenium under mild conditions to hydrogenate the keto functionality of LA selectively into an alcohol group to form 4-hydroxyvaleric acid intermediate, which yields GVL spontaneously after dehydration and cyclization.

Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies.

With the exception of renal cell carcinoma, studies assessing the association between hypertension and other cancers are inconsistent. We conducted a meta-analysis to assess this evidence. We included observational studies investigating the association between any definition of hypertension or systolic and diastolic blood pressure and risk of any cancer, after searching PubMed until November 2017.

The contribution of the medial retinaculum as a restraining factor to the patella dislocation.

The objective of this study was to evaluate the contribution of the medial retinaculum to the stability of the patella, for several angles of knee flexion. For six cadaveric knees, the patella and patella retinaculum were exposed, and the force required to dislocate the patella laterally by 5 mm was measured, in 0, 45 and 90 degrees of knee flexion, preserving and dissecting the medial retinaculum. Wilcoxon singed rank test (SPSS, version 23, Chicago, USA) was used for data analysis.

Mapping the expanded often inappropriate use of the Framingham Risk Score in the medical literature.

Objectives: To systematically evaluate the use of Framingham Risk Score (FRS) in the medical literature and specifically examine the use of FRS in different populations and settings and for different outcomes than the ones originally developed for.

Study Design And Setting: We identified all the citations to the article by Wilson et al. (1998), in which FRS was originally described through ISI Web of Science until April 2011.