[The characteristics of the effect of dipalmitoylphosphatidylcholine and its structural fragments on the lipid peroxidation of biological membranes].

The effect of dipalmitoyl phosphatidylcholine (DPPC) and its structural fragments--phosphatidic acid (PA) and choline chloride--on the ascorbate-dependent mice liver microsomal lipid peroxidation (LP) has been studied at the different LP rate. At DPPC, PA and choline chloride introduction into the incubation medium before the onset of peroxidation induction DPPC causes the more considerable inhibition of LP than PA each separate fragment. The inhibition effect of DPPC is lower than PA or choline chloride when DPPC, PA and choline chloride added on the background of developing process of peroxidation (e.

[Lipid peroxidation in subcellular organelles of the liver in thermal burns].

Variations in lipid peroxidation were observed in individual membrane structures of liver cells after burns of the IIIb degree involving 15-20% of rat body surface and studied within 1 hr, 1 day and 7 days after the thermal injury. First of all and mainly the systems of lipid peroxidation were stimulated in microsomes and mitochondria. The lysosomal lipids were involved only slightly in the total peroxidation process.

[Effect of lateral wick chain of tocopherols on oxidative reactions in lipids].

An injection of a alpha-tocopherol and analog devoid of the lateral chain (C1) at a dose of 90 mg/kg of body weight to experimental animals increases the levels of natural antioxidants and lipid oxidation in mouse liver 4- and 4.5-fold, respectively. The effects of alpha-tocopherol on the lipids possessing a high antiradical activity and containing the lateral chain and that of its analog, C1, also possessing a high antiradical activity but devoid of the lateral chain, were compared.

[Interrelationship between the level of natural antioxidants and lipid oxidation in the normal mouse liver and after injection of alpha-tocopherol].

The changes in the level of natural antioxidants and lipid oxidation in normal mouse liver and after injection of the natural antioxidant alpha-tocopherol were studied. The level of natural antioxidants and lipid oxidation were increased 1--2-fold within 24 hrs; after alpha-tocopherol injection these parameters were increased 37- and 39-fold, respectively. A direct correlation between the amount of natural antioxidants and lipid oxidation in normal mouse liver and after alpha-tocopherol injection was established.

[Effect of lecithin on liver microsomal lipid peroxidation].

The effect of exogeneous (egg) lecithin on peroxidation of microsomal lipids was studied with the view of elucidating the role of various components of lipid substrate in the overall oxidation rate of the lipids. The following processes were studied a) NADPH-dependent microsomal lipid peroxidation in the presence of lecithin; b) ascorbate-dependent microsomal lipid peroxidation in the presence of lecithin; c) oxidation of lipid mixture, isolated from the microsomes, and that of lecithin in the presence of the Fe2+ + ascorbate system; 4) oxidation of lecithin induced by the Fe2+ + ascorbate system. It was found that in the presence of exogeneous lecithin the oxidation of microsomal lipids in inhibited, which is probably due to the peculiarities of lecithin oxidation.