Publications by authors named "Arisa Yamahata"
Article Synopsis
- Non-alcoholic fatty liver disease can be simple steatosis (SS) or non-alcoholic steatohepatitis (NASH), and this study looks at the differences in lipids found in the blood of patients with these conditions.
- Researchers took blood samples from patients and studied the lipids in low-density lipoproteins (LDL) to see how they differ between those with NASH and those with SS.
- They found that patients with NASH had higher levels of certain lipids, and those levels were linked to more severe liver damage, indicating that unhealthy LDL can make liver problems worse.
Oxidized low-density lipoproteins (oxLDLs) induce oxidative stress in the liver tissue, leading to hepatic steatosis, inflammation, and fibrosis. Precise information on the role of oxLDL in this process is needed to establish strategies for the prevention and management of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Here, we report the effects of native LDL (nLDL) and oxLDL on lipid metabolism, lipid droplet formation, and gene expression in a human liver-derived C3A cell line.
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- Cardiolipin (CL) is crucial for maintaining mitochondrial structure and function, and a study investigated how a high carbohydrate diet (HCD) affects CL levels in mice's livers over 5 days.
- Results showed that total CL levels decreased by 22%, with a dramatic 93% reduction in a specific type (CL72:8), while another type (MLCL) increased by 2.4-fold.
- The study concludes that HCD alters the fatty acid composition of CL and MLCL through the regulation of Tafazzin, potentially leading to mitochondrial dysfunction, which could help understand fatty liver disease's links to mitochondrial issues.