Publications by authors named "Arinze J Ochuba"

Article Synopsis
  • Current treatments for neurodegenerative diseases face challenges due to limited neuron regeneration in the central nervous system (CNS) as it matures.
  • The study found that Ezh2, a histone methyltransferase, decreases during nerve maturation but increases after peripheral nerve injuries, aiding in spontaneous axon regeneration.
  • Overexpressing Ezh2 in retinal ganglion cells enhances optic nerve regeneration by silencing genes that inhibit regeneration and activating supportive factors, suggesting chromatin modification as a viable strategy for enhancing CNS axon regeneration.
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Percutaneous nephrolithotomy (PCNL) is the gold-standard treatment for large and complex renal stones. Though associated with higher stone-free rates compared to other minimally invasive stone procedures, this comes at the expense of increased morbidity including postoperative pain and discomfort. We describe our enhanced recovery after surgery (ERAS) protocol for PCNL with emphasis on the use of erector spinae plane blocks to improve patient satisfaction and reduce postoperative opioid use and bother.

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Objective: Patients with brachial plexus avulsion (BPA) experience chronic deafferentation pain characterized by two patterns: continuous background pain and electrical shooting paroxysmal attacks. The authors' aim was to report the effectiveness and safety of dorsal root entry zone (DREZ) lesioning in relieving the two forms of pain over short and long periods.

Methods: All patients who underwent DREZ lesioning performed by the senior author for medically refractory BPA-related pain between July 1, 2016, and June 30, 2020, in Johns Hopkins Hospital were followed up.

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Background: Achilles tendon rupture (ATR) is a common injury with a growing incidence rate. Treatment is either operative or nonoperative. However, evidence is lacking on the cost comparison between these modalities.

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Introduction: Continuous compression implants (CCI) are a fixation device formed from nitinol, a shape memory alloy. This alloy is durable enough to augment fixation and combined with its small footprint, versatile enough to insert into areas that are too small for K wires or lag screws to hold a provisional fixation.

Case Report: We used CCIs to successfully stabilize the transverse segments in three posterior column with posterior wall fractures.

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Objective: Neurogenic thoracic outlet syndrome (NTOS) is the most common form of thoracic outlet syndrome. However, NTOS has remained difficult to diagnose and treat successfully. The purpose of the present study was to generate a predictive clinical calculator for postoperative outcomes after first rib resection (FRR) for NTOS.

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Background Context: Patient activation is a patient's willingness to take independent actions to manage their own health care.

Purpose: The goal of this study is to determine whether preoperative patient activation measure (PAM) predicts minimum clinically important difference (MCID) for Patient-Reported Outcomes Measurement Information System (PROMIS) pain, physical function, depression, and anxiety for patients undergoing elective spine surgery.

Study Design/setting: Retrospective review.

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