Publications by authors named "Arina Timonina"

NaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans. Although NaPi2b is widely expressed in normal tissues, its overexpression has been demonstrated in ovarian, lung, and other cancers. A valuable set of antibodies, including L2 (20/3) and MX35, and its humanized versions react strongly with an antigen on the surface of ovarian and other carcinoma cells.

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Serine 275, a conserved residue of the left flipper region of ATP-gated P2X3 receptors, plays a key role in both agonist binding and receptor desensitization. It is conserved in most of the P2X receptors except P2X7 and P2X6. By combining experimental patch-clamp and modeling approaches, we explored the role of the corresponding residue in the rat P2X7 receptor (rP2X7) by replacing the phenylalanine at position 288 with serine and characterizing the membrane currents generated by either the wild-type (WT) or the mutated rP2X7 receptor.

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Article Synopsis
  • Serotonin (5-HT) significantly influences migraine pain by affecting the excitability of trigeminal afferents, which are crucial for pain signaling.
  • The study found that 5-HT can induce various firing patterns in nociceptive fibers, with different receptor antagonists either reducing or completely blocking its pro-nociceptive effects.
  • 5-HT shows both peripheral excitatory actions, such as increasing nociceptive firing and releasing CGRP, and central inhibitory effects that can mitigate pain signaling in the brainstem.
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