Publications by authors named "Arin Khashan"
Article Synopsis
- - This study explores the link between an anaerobic bacterium associated with periodontal disease and the development of pancreatic ductal adenocarcinoma (PDAC) by analyzing its impact in a mouse model.
- - Researchers tracked how the bacteria moved from the mouth to the pancreas and observed that it accelerated the progression from pancreatic intraepithelial neoplasia (PanIN) to PDAC while affecting cell behavior in vitro.
- - The findings suggest that this bacterium plays a significant role in promoting pancreatic cancer, indicating a potential new avenue for understanding cancer development.
is a member of the dysbiotic oral microbiome associated with oral inflammation and periodontal disease. Intriguingly, epidemiological studies link to an increased risk of pancreatic cancer. Given that oral bacteria are detected in human pancreatic cancer, and both mouse and human pancreata harbor microbiota, we explored the involvement of in pancreatic tumorigenesis using cell lines and a xenograft model.
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